Biochemical effects of sex hormones on human endometrium will be studied in whole tissue and separated glands and stroma obtained at various phasis of the menstrual cycle, as will as in cultures of these specimens and of cells derived from them. The following enzymatic activities will be used as indicators of the effect of estrogens and progestins: estradiol 17Beta dehydrogenase, peroxidase, ornithine decarboxylase, and alkaline phosphatase. The responsiveness to hormones will be correlated with the presence of estrogen and progesterone receptors. As part of this study, the variations of steroid receptor levels during the cell cycle in synchronized cultures and the day-to-day changes in these levels in non-synchronized cultures will also be investigated.

Agency
National Institute of Health (NIH)
Institute
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Type
Research Project (R01)
Project #
5R01HD007197-13
Application #
3310644
Study Section
Biochemical Endocrinology Study Section (BCE)
Project Start
1976-09-30
Project End
1986-11-30
Budget Start
1984-12-01
Budget End
1985-11-30
Support Year
13
Fiscal Year
1985
Total Cost
Indirect Cost
Name
Mount Sinai School of Medicine
Department
Type
Schools of Medicine
DUNS #
City
New York
State
NY
Country
United States
Zip Code
10029