The primary goal of this continuing project is to describe the metabolism of chondroitin SO4 in chick embryo tissues. In the coming year the work will deal with (1) the glycosyl and sulfuryl transferases involved in chondroitin SO4 biosynthesis, (2) the properties and cellular levels of the catabolic enzymes which degrade chondroitin SO4, (3) the pathway of proteochondroitin SO4 biosynthesis and secretion, including the intracellular sites of the different steps in the pathway and the effects inhibitors in interruption of the sequence in monolayer chondrocyte cultures, and (4) the cellular events involved in the release of matrix vesicles into the culture medium of chondrocyte monolayers.

Agency
National Institute of Health (NIH)
Institute
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Type
Research Project (R01)
Project #
5R01HD008057-23
Application #
3310797
Study Section
Pathobiochemistry Study Section (PBC)
Project Start
1979-06-01
Project End
1987-05-31
Budget Start
1986-06-01
Budget End
1987-05-31
Support Year
23
Fiscal Year
1986
Total Cost
Indirect Cost
Name
University of Illinois Urbana-Champaign
Department
Type
Schools of Arts and Sciences
DUNS #
041544081
City
Champaign
State
IL
Country
United States
Zip Code
61820