The objectives of the proposed studies are to gain insight into the mechanisms involved in the control and integration of the primate hypothalamic-pituitary-target tissue axes during intrauterine life and infancy. For studies in utero, a chronically catheterized fetal monkey will be employed. Endocrine regulation of the pituitary-adrenal and pituitary-gonadal systems will be studied. Studies also will be performed concerning maturation and changing sensitivity of the pituitary-adrenal and pituitary-gonadal systems in the fetal and infant monkey and the factors modulating these changes.
| Ishimoto, Hitoshi; Jaffe, Robert B (2011) Development and function of the human fetal adrenal cortex: a key component in the feto-placental unit. Endocr Rev 32:317-55 |
| Mesiano, S; Jaffe, R B (1993) Interaction of insulin-like growth factor-II and estradiol directs steroidogenesis in the human fetal adrenal toward dehydroepiandrosterone sulfate production. J Clin Endocrinol Metab 77:754-8 |
