For some years this laboratory has tested hypotheses which directly or indirectly related to the question of the etiology of trisomy in human subjects. These experiments have been endocrinologic, biochemical and cytogenetic. The present application deals directly with the diplotene stage of mouse and human meiosis with special attention to chiasmata number and location. The development of a capability for exact identification of each bivalent at diplotene makes it possible for the first time to test in mammals the basic genetical concepts of determination of chiasma number and location, sexual dimorphism, terminalization, and interchromosomal effects of structural or numerical abnormalities on chiasmata.

Agency
National Institute of Health (NIH)
Institute
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Type
Research Project (R01)
Project #
5R01HD010037-09
Application #
3311223
Study Section
Mammalian Genetics Study Section (MGN)
Project Start
1976-09-30
Project End
1987-06-30
Budget Start
1985-07-01
Budget End
1986-06-30
Support Year
9
Fiscal Year
1985
Total Cost
Indirect Cost
Name
Columbia University (N.Y.)
Department
Type
Schools of Medicine
DUNS #
064931884
City
New York
State
NY
Country
United States
Zip Code
10027
Jagiello, G; Sung, W K; Fang, J S et al. (1989) Colcemid effects on homologue pairing and crossing over during fetal mouse oogenesis. Experientia 45:482-4