Abstract

The presence of a lipase in the Ebner gland of the tongue was described by us. The lipase hydrolized triglycerides into monoglycerides, diglycerides, and fatty acids in the stomach. We have now evidence that this """"""""predigestion"""""""" by the lipase in the stomach prepares the fats for more efficient digestion in the intestines. This might be of importance in the premature and newborn. Using an animal model with diverted esophageal flow, the effect of the absence of lingual lipase on digestion is being studied. In human studies, the presence of the lipase was shown in newborns. In infants with esophageal atresia the enzyme appears in the esophagus and possibly a second lipase is present in the stomach. At present, infants with pyloric stenosis are studied to exclude regurgitation of duodenal content. Attempts are also made to purify and characterize the enzyme.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Type
Research Project (R01)
Project #
5R01HD010823-08
Application #
3311419
Study Section
Human Embryology and Development Subcommittee 2 (HED)
Project Start
1981-07-01
Project End
1986-08-31
Budget Start
1985-09-01
Budget End
1986-08-31
Support Year
8
Fiscal Year
1985
Total Cost
Indirect Cost

  Institution

Name
Georgetown University
Department
Type
Schools of Medicine
DUNS #
049515844
City
Washington
State
DC
Country
United States
Zip Code
20057

  Publications

Armand, M; Hamosh, M; DiPalma, J S et al. (1995) Dietary fat modulates gastric lipase activity in healthy humans. Am J Clin Nutr 62:74-80
Pereira, G R; Baumgart, S; Bennett, M J et al. (1994) Use of high-fat formula for premature infants with bronchopulmonary dysplasia: metabolic, pulmonary, and nutritional studies. J Pediatr 124:605-11
Jensen, R G; deJong, F A; Lambert-Davis, L G et al. (1994) Fatty acid and positional selectivities of gastric lipase from premature human infants: in vitro studies. Lipids 29:433-5
Hamosh, M; Bitman, J (1992) Human milk in disease: lipid composition. Lipids 27:848-57
Ellis, L A; Hamosh, M (1992) Bile salt stimulated lipase: comparative studies in ferret milk and lactating mammary gland. Lipids 27:917-22
Kirk, C L; Iverson, S J; Hamosh, M (1991) Lipase and pepsin activities in the stomach mucosa of the suckling dog. Biol Neonate 59:78-85
Hamosh, M (1991) Free fatty acids and monoglycerides: anti-infective agents produced during the digestion of milk fat by the newborn. Adv Exp Med Biol 310:151-8
Hamosh, M; Mehta, N R; Fink, C S et al. (1991) Fat absorption in premature infants: medium-chain triglycerides and long-chain triglycerides are absorbed from formula at similar rates. J Pediatr Gastroenterol Nutr 13:143-9
Iverson, S J; Kirk, C L; Hamosh, M et al. (1991) Milk lipid digestion in the neonatal dog: the combined actions of gastric and bile salt stimulated lipases. Biochim Biophys Acta 1083:109-19
DiPalma, J; Kirk, C L; Hamosh, M et al. (1991) Lipase and pepsin activity in the gastric mucosa of infants, children, and adults. Gastroenterology 101:116-21

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