Selective Inhibitors of Placental Steroid Aromatase

Agency: National Institute of Health (NIH)
Institute: Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Type: Research Project (R01)
Project #: 3R01HD011840-06S1
Application #: 3311686
Study Section: Bio-Organic and Natural Products Chemistry Study Section (BNP)


NIH 1993 R01 HD	Selective Inhibitors of Placental Steroid Aromatase Robinson, Cecil H. / Johns Hopkins University
NIH 1992 R01 HD	Selective Inhibitors of Placental Steroid Aromatase Robinson, Cecil H. / Johns Hopkins University
NIH 1991 R01 HD	Selective Inhibitors of Placental Steroid Aromatase Robinson, Cecil H. / Johns Hopkins University
NIH 1990 R01 HD	Selective Inhibitors of Placental Steroid Aromatase Robinson, Cecil H. / Johns Hopkins University
NIH 1989 R01 HD	Selective Inhibitors of Placental Steroid Aromatase Robinson, Cecil H. / Johns Hopkins University
NIH 1988 R01 HD	Selective Inhibitors of Placental Steroid Aromatase Robinson, Cecil H. / Johns Hopkins University
NIH 1987 R01 HD	Selective Inhibitors of Placental Steroid Aromatase Robinson, Cecil H. / Johns Hopkins University
NIH 1986 R01 HD	Selective Inhibitors of Placental Steroid Aromatase Robinson, Cecil H. / Johns Hopkins University
NIH 1985 R01 HD	Selective Inhibitors of Placental Steroid Aromatase Robinson, Cecil H. / Johns Hopkins University
NIH 1985 R01 HD	Selective Inhibitors of Placental Steroid Aromatase Robinson, Cecil H. / Johns Hopkins University

Oh, S S; Robinson, C H (1993) Mechanism of human placental aromatase: a new active site model. J Steroid Biochem Mol Biol 44:389-97

Childers, W E; Silverton, J V; Kellis Jr, J T et al. (1991) Inhibition of human placental aromatase by novel homologated 19-oxiranyl and 19-thiiranyl steroids. J Med Chem 34:1344-9

Cole, P A; Robinson, C H (1990) Mechanism and inhibition of cytochrome P-450 aromatase. J Med Chem 33:2933-42

Cole, P A; Bean, J M; Robinson, C H (1990) Conversion of a 3-desoxysteroid to 3-desoxyestrogen by human placental aromatase. Proc Natl Acad Sci U S A 87:2999-3003

Furth, P S; Rosenberger, J; Marcotte, P A et al. (1990) Synthesis of 2,2-dimethyl-4-hydroxy-4-androstene-3,17-dione as an inhibitor of aromatase. J Enzyme Inhib 4:131-5

Childers, W E; Shih, M J; Furth, P S et al. (1987) Stereoselective inhibition of human placental aromatase. Steroids 50:121-34