Agency
National Institute of Health (NIH)
Institute
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Type
Research Project (R01)
Project #
5R01HD012851-16
Application #
2196941
Study Section
Endocrinology Study Section (END)
Project Start
1979-09-30
Project End
1998-03-31
Budget Start
1996-04-01
Budget End
1998-03-31
Support Year
16
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Massachusetts General Hospital
Department
Type
DUNS #
City
Boston
State
MA
Country
United States
Zip Code
02199
Keutmann, H T; Rubin, D A (1993) A subunit interaction site in human luteinizing hormone: identification by photoaffinity cross-linking. Endocrinology 132:1305-12
Keutmann, H T; Hua, Q X; Weiss, M A (1992) Structure of a receptor-binding fragment from human luteinizing hormone beta-subunit determined by [1H]- and [15N]nuclear magnetic resonance spectroscopy. Mol Endocrinol 6:904-13
Milius, R P; Keutmann, H T; Ryan, R J (1990) Molecular modeling of residues 38-57 of the beta-subunit of human lutropin. Mol Endocrinol 4:859-68
Keutmann, H T; Mason, K A; Kitzmann, K et al. (1989) Role of the beta 93-100 determinant loop sequence in receptor binding and biological activity of human luteinizing hormone and chorionic gonadotropin. Mol Endocrinol 3:526-31
Keutmann, H T; Charlesworth, M C; Kitzmann, K et al. (1988) Primary and secondary structural determinants in the receptor binding sequence beta-(38-57) from human luteinizing hormone. Biochemistry 27:8939-44
Ryan, R J; Charlesworth, M C; McCormick, D J et al. (1988) The glycoprotein hormones: recent studies of structure-function relationships. FASEB J 2:2661-9
Amir, S M; Kubota, K; Tramontano, D et al. (1987) The carbohydrate moiety of bovine thyrotropin is essential for full bioactivity but not for receptor recognition. Endocrinology 120:345-52
Ryan, R J; Keutmann, H T; Charlesworth, M C et al. (1987) Structure-function relationships of gonadotropins. Recent Prog Horm Res 43:383-429
Keutmann, H T; Charlesworth, M C; Mason, K A et al. (1987) A receptor-binding region in human choriogonadotropin/lutropin beta subunit. Proc Natl Acad Sci U S A 84:2038-42
Calvo, F O; Keutmann, H T; Bergert, E R et al. (1986) Deglycosylated human follitropin: characterization and effects on adenosine cyclic 3',5'-phosphate production in porcine granulosa cells. Biochemistry 25:3938-43

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