Abstract

The study continues investigations into the nature of energy metabolism in the fetus. A chronic fetal lamb preparation and a chronic nonhuman primate model, the fetal baboon, are being used to extend previous studies of quantitative energy metabolism. Substrate uptake and production by the fetal animals is being evaluated by utilizing appropriately placed arterial and venous catheters for sampling arteriovenous metabolic differences, radioactive precursor tracer techniques, and measures of fetal blood flow and specific organ blood flows. We plan to study the capacity of the fetus to control gluconeogenesis, glycogenesis, and glycogenolysis in the face of a hostile maternal metabolic milieu, focusing particularly on endogenous hormonal or substrate mediated control mechanisms. In addition, pharmacologic probes of hormonal control mechanisms will be employed during steady state conditions in the pregnant animal. These studies are immediately relevant to the clinical problems of the infant of the diabetic mother, who may be exposed to acute hypoglycemia, or acute and chronic hyperglycemia, and to the infant of the calorically deprived, undernourished mother.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Type
Research Project (R01)
Project #
2R01HD013138-05A1
Application #
3312093
Study Section
Metabolism Study Section (MET)
Project Start
1979-07-01
Project End
1988-11-30
Budget Start
1984-12-01
Budget End
1985-11-30
Support Year
5
Fiscal Year
1985
Total Cost
Indirect Cost

  Institution

Name
Michael Reese Hosp & Medical Center (Chicago)
Department
Type
DUNS #
City
Chicago
State
IL
Country
United States
Zip Code
60616

  Publications

Peddada, Sailaja; Yasui, Dag H; LaSalle, Janine M (2006) Inhibitors of differentiation (ID1, ID2, ID3 and ID4) genes are neuronal targets of MeCP2 that are elevated in Rett syndrome. Hum Mol Genet 15:2003-14
Ishiguro, Hiroki; Liu, Qing-Rong; Gong, Jian-Ping et al. (2006) NrCAM in addiction vulnerability: positional cloning, drug-regulation, haplotype-specific expression, and altered drug reward in knockout mice. Neuropsychopharmacology 31:572-84
Kishore, Shivendra; Stamm, Stefan (2006) The snoRNA HBII-52 regulates alternative splicing of the serotonin receptor 2C. Science 311:230-2
Samaco, Rodney C; Hogart, Amber; LaSalle, Janine M (2005) Epigenetic overlap in autism-spectrum neurodevelopmental disorders: MECP2 deficiency causes reduced expression of UBE3A and GABRB3. Hum Mol Genet 14:483-92
Thatcher, Karen N; Peddada, Sailaja; Yasui, Dag H et al. (2005) Homologous pairing of 15q11-13 imprinted domains in brain is developmentally regulated but deficient in Rett and autism samples. Hum Mol Genet 14:785-97
Perlman, W R; Matsumoto, M; Beltaifa, S et al. (2005) Expression of estrogen receptor alpha exon-deleted mRNA variants in the human and non-human primate frontal cortex. Neuroscience 134:81-95
Singh, Ram P; Liu, Dahai; Chaudhari, Abhijit et al. (2004) Investigation of different transcript quantitation tools for high-throughput mapping of brain gene expression using voxelation. J Mol Histol 35:397-402
Palmen, Saskia J M C; van Engeland, Herman; Hof, Patrick R et al. (2004) Neuropathological findings in autism. Brain 127:2572-83
Braunschweig, Daniel; Simcox, Thomas; Samaco, Rodney C et al. (2004) X-Chromosome inactivation ratios affect wild-type MeCP2 expression within mosaic Rett syndrome and Mecp2-/+ mouse brain. Hum Mol Genet 13:1275-86
Samaco, Rodney C; Nagarajan, Raman P; Braunschweig, Daniel et al. (2004) Multiple pathways regulate MeCP2 expression in normal brain development and exhibit defects in autism-spectrum disorders. Hum Mol Genet 13:629-39

Showing the most recent 10 out of 29 publications