Agency
National Institute of Health (NIH)
Institute
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Type
Research Project (R01)
Project #
5R01HD013250-16
Application #
2196988
Study Section
Pharmacology A Study Section (PHRA)
Project Start
1979-09-30
Project End
1996-04-30
Budget Start
1994-05-01
Budget End
1996-04-30
Support Year
16
Fiscal Year
1994
Total Cost
Indirect Cost
Name
University of Kentucky
Department
Pharmacology
Type
Schools of Medicine
DUNS #
832127323
City
Lexington
State
KY
Country
United States
Zip Code
40506
Vore, M; Liu, Y; Huang, L (1997) Cholestatic properties and hepatic transport of steroid glucuronides. Drug Metab Rev 29:183-203
Vore, M; Hoffman, T; Gosland, M (1996) ATP-dependent transport of beta-estradiol 17-(beta-D-glucuronide) in rat canalicular membrane vesicles. Am J Physiol 271:G791-8
Liu, Y; Huang, L; Hoffman, T et al. (1996) MDR1 substrates/modulators protect against beta-estradiol-17beta-D-glucuronide cholestasis in rat liver. Cancer Res 56:4992-7
Liu, Y; Ganguly, T; Hyde, J F et al. (1995) Prolactin increases mRNA encoding Na(+)-TC cotransport polypeptide and hepatic Na(+)-TC cotransport. Am J Physiol 268:G11-7
Ganguly, T C; Liu, Y; Hyde, J F et al. (1994) Prolactin increases hepatic Na+/taurocholate co-transport activity and messenger RNA post partum. Biochem J 303 ( Pt 1):33-6
Vore, M; Hoffman, T (1994) Carrier-mediated electrogenic transport of estradiol-17 beta-glucuronide in rat liver BMV. Am J Physiol 267:G546-51
Gosland, M; Tsuboi, C; Hoffman, T et al. (1993) 17 beta-estradiol glucuronide: an inducer of cholestasis and a physiological substrate for the multidrug resistance transporter. Cancer Res 53:5382-5
Ganguly, T; Hyde, J F; Vore, M (1993) Prolactin increases Na+/taurocholate cotransport in isolated hepatocytes from postpartum rats and ovariectomized rats. J Pharmacol Exp Ther 267:82-7
Liu, Y; Hyde, J F; Vore, M (1992) Prolactin regulates maternal bile secretory function post partum. J Pharmacol Exp Ther 261:560-6
Zimniak, P; Ziller 3rd, S A; Panfil, I et al. (1992) Identification of an anion-transport ATPase that catalyzes glutathione conjugate-dependent ATP hydrolysis in canalicular plasma membranes from normal rats and rats with conjugated hyperbilirubinemia (GY mutant). Arch Biochem Biophys 292:534-8

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