The methods developed for the synthesis of hormonal and anti-inflammatory steroids will be applied to the synthesis of optically active cortisone and aldosterone. New methods will be explored for the induction of opticla activity through sigmatropic rearrangements. Steroifs play an important role in human health and development as anti-inflammatory, anti-fertility, and symbiotic anti-tumor agents.

Agency
National Institute of Health (NIH)
Institute
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Type
Research Project (R01)
Project #
5R01HD014669-06
Application #
3312749
Study Section
Medicinal Chemistry Study Section (MCHA)
Project Start
1981-03-01
Project End
1987-12-31
Budget Start
1986-04-01
Budget End
1987-12-31
Support Year
6
Fiscal Year
1986
Total Cost
Indirect Cost
Name
Yale University
Department
Type
Schools of Arts and Sciences
DUNS #
082359691
City
New Haven
State
CT
Country
United States
Zip Code
06520