Abstract

The aims of this proposal are: 1) To characterize the effects of protein binding, albumin and specific globulins on the biological activity and/or metabolism of androgens and cortisol. These studies are to be done using dynamic, steady-state perfusions of specific tissues and cell suspensions in vitro and to evaluate these effects in vivo in cynomologous monkeys using constant infusions and measuring extraction and metabolism across the splanchnic bed and an extremity, and 2) To determine the site for the increase in aromatization noted in liver disease through the use of constant infusions of labeled androgens and estrogens in cynomologous monkeys before and after the production of cirrhosis.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Type
Research Project (R01)
Project #
2R01HD015443-04A1
Application #
3313088
Study Section
Biochemical Endocrinology Study Section (BCE)
Project Start
1981-04-01
Project End
1987-11-30
Budget Start
1984-12-01
Budget End
1985-11-30
Support Year
4
Fiscal Year
1985
Total Cost
Indirect Cost

  Institution

Name
University of Massachusetts Medical School Worcester
Department
Type
Schools of Medicine
DUNS #
660735098
City
Worcester
State
MA
Country
United States
Zip Code

  Publications

Longcope, C (1990) Hormone dynamics at the menopause. Ann N Y Acad Sci 592:21-30;discussion 44-51
Reilly, J; Sadowski, S; Wolfe, T et al. (1990) Effects of serum proteins on estrogen action in the perfused rat liver. Steroids 55:40-4
Bourget, C; Femino, A; Franz, C et al. (1988) Estrogen and androgen dynamics in the cynomolgus monkey. Endocrinology 122:202-6
Reilly, J; Rafkind, I; Longcope, C (1987) Effect of serum proteins on estrogen-mediated receptor translocation in the superfused rat uterus. J Steroid Biochem 28:717-22
Longcope, C; Yosha, S; Young, R A et al. (1987) The effects of low-protein diet and testosterone on sex hormone-binding globulin capacity in male rabbits. Metabolism 36:703-7
Orczyk, G P; Mordes, J P; Longcope, C (1987) Aromatase activity in a rat Leydig cell tumor. Endocrinology 120:1482-9
Longcope, C; Hui, S L; Johnston Jr, C C (1987) Free estradiol, free testosterone, and sex hormone-binding globulin in perimenopausal women. J Clin Endocrinol Metab 64:513-8
Zyirek, M; Flood, C; Longcope, C (1987) 5 alpha-reductase activity in rat adipose tissue. Proc Soc Exp Biol Med 186:134-8
Bourget, C; Femino, A; Franz, C et al. (1987) The effects of l-thyroxine and dexamethasone on steroid dynamics in male cynomologous monkeys. J Steroid Biochem 28:575-9
Longcope, C (1987) Peripheral aromatization: studies on controlling factors. Steroids 50:253-67

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