The overall goal is to elucidate further the causes of abnormal prenatal development through the study of spontaneous abortions of known karyotype and morphology. Risk factors will be derived from analyses of the extensive and systematic histories collected for about 2700 women with chromosomally normal (euploid) and chromosomally abnormal (aneuploid) spontaneous abortions and 4400 control women delivering at 28 weeks gestation or later. These data were collected over a twelve year period in three New York City hospitals. Analyses of these data, throughout the period of collection, have yielded a number of insights on determinants for euploid and aneuploid spontaneous abortion. Further analyses are proposed to replicate and elaborate some associations, to explore inconsistencies further (over time or with sociodemographic characteristics) in the associations of other exposures with spontaneous abortion, and to examine new research questions.
The specific aims are to: describe the epidemiology of euploid spontaneous abortion, including a first effort to study systematically risk factors for fetal and non-fetal losses; describe the epidemiology of trisomy; examine whether nausea is an indicator of the viability of the pregnancy; for length of time to conception, to identify risk factors, and seek associations with karyotype; analyze data relating to DNA adduct formation in the fetuses of smokers; develop a systematic study of early (subclinical) pregnancy loss.

Agency
National Institute of Health (NIH)
Institute
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Type
Research Project (R01)
Project #
5R01HD015909-07
Application #
3313308
Study Section
Epidemiology and Disease Control Subcommittee 3 (EDC)
Project Start
1982-04-01
Project End
1989-11-30
Budget Start
1987-12-01
Budget End
1988-11-30
Support Year
7
Fiscal Year
1988
Total Cost
Indirect Cost
Name
New York State Psychiatric Institute
Department
Type
DUNS #
167204994
City
New York
State
NY
Country
United States
Zip Code
10032
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Hatch, M C; Warburton, D; Santella, R M (1990) Polycyclic aromatic hydrocarbon-DNA adducts in spontaneously aborted fetal tissue. Carcinogenesis 11:1673-5
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Stein, Z A (1985) A woman's age: childbearing and child rearing. Am J Epidemiol 121:327-42
Kline, J; Stein, Z; Susser, M et al. (1985) Fever during pregnancy and spontaneous abortion. Am J Epidemiol 121:832-42
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