Taurine is an essential amino acid for cats, and if not supplied in the diet, they become taurine depleted and suffer retinal and tapetum degeneration. Nursing cats supply the kittens with all of their nutrition, including taurine, which comprises the major portion of the free amino acid pool of cat's milk, presumably to supply this great need during development. We propose to examine the additional nutritional stress of pregnancy and lactation on cats receiving no dietary taurine. We will examine both the queen and the kittens, and their nutrition link, the milk, throughout the period of weaning. A nursing cat transfers the major portion of its body taurine to the kittens via the milk from birth to weaning, and since the cat has only a small capacity for biosynthesizing taurine, nutritional taurine takes on additional importance. Preliminary experiments suggest that dietary depletion of taurine during pregnancy results in resorbtions, abortions, stillbirths, and live, underweight kittens. Such kittens have a number of neurological defects. All queens and kittens will be examined for the following: reduced growth, changes in taurine concentration in plasma, in tissues, and in the milk, whether lactation continues normally, any obvious behavioral or clinical signs, and any defects in the retinas ophthalmoscopically, in electroretinograms, in visual evoked potentials, and ultrastructurally. These observations will be made when the diet is initiated after various lengths of gestation, and prior to conception. Prenatal and postnatal effects will be differentiated by cross-fostering, and by oral taurine supplementation. Experiments with graded levels of taurine in the diet will provide the minimum taurine requirement for normal pregnancy and for normal postnatal development. The degree to which cystine supplements can spare dietary taurine will be determined. The effects of nutritional taurine inadequacy during pregnancy and lactation should be greatest in the cat because of its rapid growth and greater dependence on taurine. However, human and non-human primate infants become taurine-depleted and suffer from some retinal problems and growth depression under taurine-free nutrition, since they also derive all of their taurine from the milk and have an even smaller capacity for taurine biosynthesis than the cat. The results from the proposed study will be useful predictor of the importance of dietary taurine to pregnancy and nursing in these species.

Agency
National Institute of Health (NIH)
Institute
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Type
Research Project (R01)
Project #
5R01HD016634-03
Application #
3313801
Study Section
Nutrition Study Section (NTN)
Project Start
1983-12-01
Project End
1986-11-30
Budget Start
1985-12-01
Budget End
1986-11-30
Support Year
3
Fiscal Year
1986
Total Cost
Indirect Cost
Name
Institute for Basic Research in Dev Disabil
Department
Type
DUNS #
167205090
City
Staten Island
State
NY
Country
United States
Zip Code
10314
Lu, P; Sturman, J A; Bolton, D C (1995) Altered GABA distribution in hamster brain is an early molecular consequence of infection by scrapie prions. Brain Res 681:235-41
Sturman, J A; Chesney, R W (1995) Taurine in pediatric nutrition. Pediatr Clin North Am 42:879-97
Sturman, J A; Lu, P; Xu, Y X et al. (1994) Feline maternal taurine deficiency: effects on visual cortex of the offspring. A morphometric and immunohistochemical study. Adv Exp Med Biol 359:369-84
Sturman, J A (1993) Taurine in development. Physiol Rev 73:119-47
Quesada, O; Lu, P; Sturman, J A (1993) Taurine distribution in different cat muscles as visualized by immunohistochemistry: changes with stimulus state. Cytobios 73:143-54
Lu, P; Imaki, H; Xu, W et al. (1993) Visualization of taurine, GABA and glutamate in developing feline cerebellum by immunohistochemistry. Int J Dev Neurosci 11:493-505
Sturman, J A; Messing, J M (1992) High dietary taurine effects on feline tissue taurine concentrations and reproductive performance. J Nutr 122:82-8
Sturman, J A; Messing, J M (1992) High dietary taurine and feline reproduction. Adv Exp Med Biol 315:91-8
Fox, P R; Sturman, J A (1992) Myocardial taurine concentrations in cats with cardiac disease and in healthy cats fed taurine-modified diets. Am J Vet Res 53:237-41
Sturman, J A (1991) Dietary taurine and feline reproduction and development. J Nutr 121:S166-70

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