Agency
National Institute of Health (NIH)
Institute
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Type
Research Project (R01)
Project #
3R01HD017484-03S1
Application #
3314483
Study Section
Reproductive Biology Study Section (REB)
Project Start
1983-04-01
Project End
1986-06-30
Budget Start
1985-04-01
Budget End
1986-06-30
Support Year
3
Fiscal Year
1986
Total Cost
Indirect Cost
Name
University of Minnesota Twin Cities
Department
Type
Schools of Medicine
DUNS #
168559177
City
Minneapolis
State
MN
Country
United States
Zip Code
55455
Graeff, Richard; Lee, Hon Cheung (2002) A novel cycling assay for nicotinic acid-adenine dinucleotide phosphate with nanomolar sensitivity. Biochem J 367:163-8
Graeff, Richard; Lee, Hon Cheung (2002) A novel cycling assay for cellular cADP-ribose with nanomolar sensitivity. Biochem J 361:379-84
Graeff, R; Munshi, C; Aarhus, R et al. (2001) A single residue at the active site of CD38 determines its NAD cyclizing and hydrolyzing activities. J Biol Chem 276:12169-73
Lee, H C (2001) Physiological functions of cyclic ADP-ribose and NAADP as calcium messengers. Annu Rev Pharmacol Toxicol 41:317-45
Lee, H C; Aarhus, R (2000) Functional visualization of the separate but interacting calcium stores sensitive to NAADP and cyclic ADP-ribose. J Cell Sci 113 Pt 24:4413-20
Khoo, K M; Han, M K; Park, J B et al. (2000) Localization of the cyclic ADP-ribose-dependent calcium signaling pathway in hepatocyte nucleus. J Biol Chem 275:24807-17
Lee, H C (2000) NAADP: An emerging calcium signaling molecule. J Membr Biol 173:8-Jan
Munshi, C; Aarhus, R; Graeff, R et al. (2000) Identification of the enzymatic active site of CD38 by site-directed mutagenesis. J Biol Chem 275:21566-71
Lee, H C (1999) A unified mechanism of enzymatic synthesis of two calcium messengers: cyclic ADP-ribose and NAADP. Biol Chem 380:785-93
Wong, L; Aarhus, R; Lee, H C et al. (1999) Cyclic 3-deaza-adenosine diphosphoribose: a potent and stable analog of cyclic ADP-ribose. Biochim Biophys Acta 1472:555-64

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