Abstract

The overall objective of this research program is to clarify the role of the brain and endocrine stimuli in the regulation of pulsatile LH release. Specific areas of investigation will include the influence of various CNS areas on pulsatile LH release, the role of neurotransmitters such as serotonin or dopamine in mediating any observed effects, the parameters of pulsatile LH release affected, i.e., LH interpulse interval or LH pulse magnitude, and possible modification of brain serotoninergic function by estrogen.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Type
Research Project (R01)
Project #
5R01HD017728-04
Application #
3314755
Study Section
Biochemical Endocrinology Study Section (BCE)
Project Start
1982-09-01
Project End
1987-03-31
Budget Start
1985-09-01
Budget End
1987-03-31
Support Year
4
Fiscal Year
1985
Total Cost
Indirect Cost

  Institution

Name
University of Connecticut
Department
Type
Schools of Arts and Sciences
DUNS #
City
Storrs-Mansfield
State
CT
Country
United States
Zip Code

  Publications

Smith, M J; Gallo, R V (1997) Further studies on the suppression of luteinizing hormone release due to activation of medial preoptic-anterior hypothalamic area mu-opioid receptors. Brain Res Bull 42:1-7
Smith, M J; Gallo, R V (1997) The effect of blockade of kappa-opioid receptors in the medial preoptic area on the luteinizing hormone surge in the proestrous rat. Brain Res 768:111-9
Zhen, S; Gallo, R V (1995) The role of norepinephrine in mediating luteinizing hormone release in response to blockade of kappa-opioid receptors in the medial preoptic area. Brain Res 698:121-9
Zhen, S; Gallo, R V (1994) Lack of catecholamine involvement in the increased luteinizing hormone release due to blockade of kappa-opioid receptors in the medial basal hypothalamus during midpregnancy in the rat. Brain Res 642:178-84
Veldhuis, J D; Johnson, M L; Gallo, R V (1993) Reanalysis of the rat proestrous LH surge by deconvolution analysis. Am J Physiol 265:R240-5
Zhen, S; Gallo, R V (1992) The effect of blockade of kappa-opioid receptors in the medial basal hypothalamus and medial preoptic area on luteinizing hormone release during midpregnancy in the rat. Endocrinology 131:1650-6
Mallory, D S; Gallo, R V (1990) Medial preoptic-anterior hypothalamic area involvement in the suppression of pulsatile LH release by a mu-opioid agonist in the ovariectomized rat. Brain Res Bull 25:251-7
Mallory, D S; Bona-Gallo, A; Gallo, R V (1989) Neurotransmitter involvement in naloxone-induced stimulation of pulsatile LH release on day 8 of pregnancy in the rat. Brain Res Bull 22:1015-21
Babu, G N; Bona-Gallo, A; Gallo, R V (1988) Analysis of estradiol-independent and -dependent endogenous opioid peptide suppression of pulsatile LH release between the mornings of diestrus 2 and proestrus in the rat estrous cycle. Brain Res Bull 21:277-84
Devorshak-Harvey, E; Bona-Gallo, A; Gallo, R V (1988) Declining plasma progesterone levels eliminate endogenous opioid peptide suppression of LH pulse frequency on day 22 of gestation in the rat. Neuroendocrinology 48:584-90

Showing the most recent 10 out of 25 publications