Abstract

The Pediatric Drug Surveillance (""""""""PeDS"""""""") Program is an epidemiologic study of the clinical effects of drugs in hospitalized children. The objectives of this research project are to study the acute and long-term clinical effects of drugs in the pediatric population; in particular, we intend to identify previously unsuspected acute effects of drugs and previously unsuspected relationships between specific diseases and drugs used on an out-patient basis. In addition, the project seeks to evaluate patient factors that may influence the outcome of drug therapy. Given the relative lack of information about drug effects in the newborn, this project intends to study the effects of drugs in the newborn with particular emphasis. This project also seeks to address certain methodologic issues related to intensive drug surveillance; for example, we intend to evaluate both the feasibility and utility of conducting drug surveillance in community hospitals. Finally, to increase the efficiency of in-hospital intensive drug surveillance, the project will develop methods that utilize existing hospital computer files to obtain information currently obtained through other means.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Type
Research Project (R01)
Project #
5R01HD017958-07
Application #
3314939
Study Section
Epidemiology and Disease Control Subcommittee 3 (EDC)
Project Start
1978-05-01
Project End
1987-03-31
Budget Start
1985-04-01
Budget End
1987-03-31
Support Year
7
Fiscal Year
1985
Total Cost
Indirect Cost

  Institution

Name
Children's Hospital Boston
Department
Type
DUNS #
076593722
City
Boston
State
MA
Country
United States
Zip Code

  Publications

Lesko, S M; Mitchell, A A (1994) Total bilirubin level in relation to excipients in parenteral morphine sulfate administered to seriously ill newborn infants. Paediatr Perinat Epidemiol 8:401-10
Lesko, S M; Epstein, M F; Mitchell, A A (1990) Recent patterns of drug use in newborn intensive care. J Pediatr 116:985-90
Freeman, J; Lesko, S M; Mitchell, A A et al. (1990) Hyperbilirubinemia following exposure to pancuronium bromide in newborns. Dev Pharmacol Ther 14:209-15
Mitchell, A A; Lacouture, P G; Sheehan, J E et al. (1988) Adverse drug reactions in children leading to hospital admission. Pediatrics 82:24-9
Lacouture, P G; Epstein, M F; Mitchell, A A (1987) Vancomycin-associated shock and rash in newborn infants. J Pediatr 111:615-6
Lesko, S M; Mitchell, A A; Epstein, M F et al. (1986) Heparin use as a risk factor for intraventricular hemorrhage in low-birth-weight infants. N Engl J Med 314:1156-60