Abstract

The long-term objectives of this project are: (1) to determine the pathologic physiology of the menstrual disorders now encountered with increasing frequency in women athletes (delayed menarche, secondary oligo-amenorrhea, infertility attributable to inadequacy of the luteal phase, and dysfunctional uterine bleeding). (2) To utilize such knowledge to devise therapy that will restore menstrual cyclicity in individuals continuing to exercise. At least three hormones with potentially anti-reproductive effects are now known to increase during exercise: melatonin, B-endorphin and prolactin. Accordingly, pharmacologic blocking drugs are being employed in an attempt to delineate the metabolic pathways activated by the stimulus of exercise.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Type
Research Project (R01)
Project #
3R01HD018999-03S1
Application #
3316142
Study Section
(SSS)
Project Start
1984-07-01
Project End
1987-12-31
Budget Start
1987-07-01
Budget End
1987-12-31
Support Year
3
Fiscal Year
1987
Total Cost
Indirect Cost

  Institution

Name
Boston University
Department
Type
Sch Allied Health Professions
DUNS #
604483045
City
Boston
State
MA
Country
United States
Zip Code
02118

  Publications

Williams, N I; Bullen, B A; McArthur, J W et al. (1999) Effects of short-term strenuous endurance exercise upon corpus luteum function. Med Sci Sports Exerc 31:949-58
Williams, N I; Young, J C; McArthur, J W et al. (1995) Strenuous exercise with caloric restriction: effect on luteinizing hormone secretion. Med Sci Sports Exerc 27:1390-8
Williams, N I; McArthur, J W; Turnbull, B A et al. (1994) Effects of follicular phase exercise on luteinizing hormone pulse characteristics in sedentary eumenorrhoeic women. Clin Endocrinol (Oxf) 41:787-94
McArthur, J W; Turnbull, B A; Pehrson, J et al. (1993) Nalmefene enhances LH secretion in a proportion of oligo-amenorrheic athletes. Acta Endocrinol (Copenh) 128:325-33
Skrinar, G S; Williams, N I; Bullen, B A et al. (1992) Changes in body consciousness relate to regularity of exercise training. Percept Mot Skills 75:696-8
Beitins, I Z; McArthur, J W; Turnbull, B A et al. (1991) Exercise induces two types of human luteal dysfunction: confirmation by urinary free progesterone. J Clin Endocrinol Metab 72:1350-8
McArthur, J W; Gilbert, I; Henery, R J et al. (1990) The effects of submaximal endurance exercise upon LH pulsatility. Clin Endocrinol (Oxf) 32:115-26
Peachey, S E; Skrinar, G S; Leeman, S E et al. (1989) Effect of acute exercise on plasma neurotensin levels. Peptides 10:753-6
Henery, R J; Turnbull, B A; Kirkland, M et al. (1989) The detection of peaks in luteinizing hormone secretion. Chronobiol Int 6:259-65