Agency
National Institute of Health (NIH)
Institute
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Type
Research Project (R01)
Project #
5R01HD022095-08
Application #
2198451
Study Section
Toxicology Subcommittee 2 (TOX)
Project Start
1987-08-01
Project End
1997-11-30
Budget Start
1995-12-01
Budget End
1996-11-30
Support Year
8
Fiscal Year
1996
Total Cost
Indirect Cost
Name
University of Washington
Department
Pediatrics
Type
Schools of Medicine
DUNS #
135646524
City
Seattle
State
WA
Country
United States
Zip Code
98195
Mirkes, P E; Cornel, L M; Wilson, K L et al. (1999) Heat shock protein 70 (Hsp70) protects postimplantation murine embryos from the embryolethal effects of hyperthermia. Dev Dyn 214:159-70
Thayer, J M; Mirkes, P E (1997) Induction of Hsp72 and transient nuclear localization of Hsp73 and Hsp72 correlate with the acquisition and loss of thermotolerance in postimplantation rat embryos. Dev Dyn 208:227-43
Mirkes, P E; Cornel, L M; Park, H W et al. (1997) Induction of thermotolerance in early postimplantation rat embryos is associated with increased resistance to hyperthermia-induced apoptosis. Teratology 56:210-9
Bratton, S L; Jardine, D S; Mirkes, P E (1997) Constitutive synthesis of heat shock protein (72 kD) in human peripheral blood mononuclear cells: implications for use as a clinical test of recent thermal stress. Int J Hyperthermia 13:157-68
Mirkes, P E; Little, S A; Cornel, L et al. (1996) Induction of heat shock protein 27 in rat embryos exposed to hyperthermia. Mol Reprod Dev 45:276-84
Little, S A; Mirkes, P E (1995) Clusterin expression during programmed and teratogen-induced cell death in the postimplantation rat embryo. Teratology 52:41-54
Thayer, J M; Mirkes, P E (1995) Programmed cell death and N-acetoxy-2-acetylaminofluorene-induced apoptosis in the rat embryo. Teratology 51:418-29
Fujinaga, M; Park, H W; Shepard, T H et al. (1994) Staurosporine does not prevent adrenergic-induced situs inversus, but causes a unique syndrome of defects in rat embryos grown in culture. Teratology 50:261-74
Mirkes, P E; Doggett, B; Cornel, L (1994) Induction of a heat shock response (HSP 72) in rat embryos exposed to selected chemical teratogens. Teratology 49:135-42
Cunningham, M L; Mac Auley, A; Mirkes, P E (1994) From gastrulation to neurulation: transition in retinoic acid sensitivity identifies distinct stages of neural patterning in the rat. Dev Dyn 200:227-41

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