Due to the rapidly changing social status and the role of females in the western as well as in developing countries, male contraceptives are greatly in demand. Despite this, no significant progress has been made in the area of male fertility control. This proposal is based on the lead compound, (S)-DHPA, which has shown a remarkable inhibitory activity on spermatogenesis in mice. In order to confirm the activity, the synthesis and tests of (S)-DHPA in rats are proposed. In order to study the structure-activity relationships, (S)-DHPA derivatives containing various purine rings will be synthesized. Further structure activity relationships will be explored with C-nucleoside analogs of (S)-DHPA. The long term objective of this project is to develop a clinically safe, effective, and reversible male contraceptive.

Agency
National Institute of Health (NIH)
Institute
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Type
Research Project (R01)
Project #
5R01HD022155-03
Application #
3321537
Study Section
Reproductive Endocrinology Study Section (REN)
Project Start
1986-07-01
Project End
1989-06-30
Budget Start
1988-07-01
Budget End
1989-06-30
Support Year
3
Fiscal Year
1988
Total Cost
Indirect Cost
Name
University of Georgia
Department
Type
Schools of Pharmacy
DUNS #
City
Athens
State
GA
Country
United States
Zip Code
30602