In-vivo studies of the menstrual cycle present enormous challenges, as they deal with a complex entity which is the result of multiple interactions between a large number of variables, not all of which can be controlled at one time in an in-vivo setting. Adjunct or alternative approaches to the in-vivo study of the human reproductive cycle have been suggested, among which is the computer simulation approach. This research proposal represents an attempt to evaluate the validity of this approach. The investigators propose to resume their studies with a computer model of the cyclic morphological and endocrine changes which characterize the menstrual cycle. The proposal contains three practical aims.
The first aim i s to refine the original menstrual cycle computer simulation model. This model was developed more than a decade ago; new data and concepts must now be evaluated, tested and, where required, integrated into the model.
The second aim i s to develop a sophisticated user interface. The model will be adapted to PC desktop type computer hardware and will incorporate principles of what are called """"""""expert system"""""""" programs. This will allow physiologists to test and use the computer model in a highly sophisticated, yet easily controllable fashion without the need for an extensive computer background.
The third aim i s to test the utility of this computer modeling approach in an experimental setting. Selected experimentalists will provide us with an experimental setting. Selected experimentalists will provide us with an objective analysis of the model through their ability to log simulation results. Ultimately, a refined and validated model of the menstrual cycle can be used to assist in both experimental design and result interpretation and thereby enhance knowledge gained from in-vivo experimentation.

Agency
National Institute of Health (NIH)
Institute
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Type
Research Project (R01)
Project #
5R01HD022209-03
Application #
3321661
Study Section
Reproductive Biology Study Section (REB)
Project Start
1987-05-01
Project End
1990-04-30
Budget Start
1989-05-01
Budget End
1990-04-30
Support Year
3
Fiscal Year
1989
Total Cost
Indirect Cost
Name
Columbia University (N.Y.)
Department
Type
Schools of Medicine
DUNS #
064931884
City
New York
State
NY
Country
United States
Zip Code
10027