Women's health problems, especially endometriosis, are of top priority. Isolation of specific endometrial antigens eliciting autoimmunity in endometriosis is the desired goal, so that an endometrial antigen-specific antibody assay can be developed for a non-invasive diagnosis and monitoring of endometriosis In women of all races and from all areas in U.S.A.. The research goals are: (1) To elute antigens specifically binding to serum or peritoneal fluid IgG in patients with endometriosis, from the native and cultured endometria / endometriosis implants. (2) To isolate the antigens of interest using polyclonal antibodies. (3) To use the polyclonal and monoclonal antibodies to isolate sufficient quantities of these antigens to develop a specific endometrial antibody assay for the clinical diagnosis and management of endometriosis.
| Mathur, S P; Lee, J H; Jiang, H et al. (1999) Levels of transferrin and alpha 2-HS glycoprotein in women with and without endometriosis. Autoimmunity 29:121-7 |
| Pillai, S; Zhou, G X; Arnaud, P et al. (1996) Antibodies to endometrial transferrin and alpha 2-Heremans Schmidt (HS) glycoprotein in patients with endometriosis. Am J Reprod Immunol 35:483-94 |
| Mathur, S; Butler, W J; Chihal, H J et al. (1995) Target antigen(s) in endometrial autoimmunity of endometriosis. Autoimmunity 20:211-22 |
