Agency
National Institute of Health (NIH)
Institute
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Type
Research Project (R01)
Project #
2R01HD027981-04
Application #
2200801
Study Section
Mammalian Genetics Study Section (MGN)
Project Start
1993-09-01
Project End
1999-08-31
Budget Start
1996-09-01
Budget End
1997-08-31
Support Year
4
Fiscal Year
1996
Total Cost
Indirect Cost
Name
University of Houston
Department
Biology
Type
Schools of Arts and Sciences
DUNS #
800771594
City
Houston
State
TX
Country
United States
Zip Code
77204
Hilton, Matthew J; Gutierrez, Laura; Martinez, Daniel A et al. (2005) EXT1 regulates chondrocyte proliferation and differentiation during endochondral bone development. Bone 36:379-86
Hilton, Matthew J; Sawyer, Jacob M; Gutierrez, Laura et al. (2002) Analysis of novel and recurrent mutations responsible for the tricho-rhino-phalangeal syndromes. J Hum Genet 47:103-6
Hill, A L; Brown, N; Hill, M S et al. (2002) Identification of the Xenopus laevis cDNA for EXT1: a phylogenetic perspective. DNA Seq 13:85-92
Hilton, M J; Gutierrez, L; Zhang, L et al. (2001) An integrated physical map of 8q22-q24: use in positional cloning and deletion analysis of Langer-Giedion syndrome. Genomics 71:192-9
Lin, X; Wei, G; Shi, Z et al. (2000) Disruption of gastrulation and heparan sulfate biosynthesis in EXT1-deficient mice. Dev Biol 224:299-311
Raskind, W H; Conrad 3rd, E U; Matsushita, M et al. (1998) Evaluation of locus heterogeneity and EXT1 mutations in 34 families with hereditary multiple exostoses. Hum Mutat 11:231-9
Lin, X; Gan, L; Klein, W H et al. (1998) Expression and functional analysis of mouse EXT1, a homolog of the human multiple exostoses type 1 gene. Biochem Biophys Res Commun 248:738-43
Philippe, C; Porter, D E; Emerton, M E et al. (1997) Mutation screening of the EXT1 and EXT2 genes in patients with hereditary multiple exostoses. Am J Hum Genet 61:520-8
Lin, X; Wells, D E (1997) Localization of the human H3F3A histone gene to 1q41, outside of the normal histone gene clusters. Genomics 46:526-8
Hecht, J T; Hogue, D; Wang, Y et al. (1997) Hereditary multiple exostoses (EXT): mutational studies of familial EXT1 cases and EXT-associated malignancies. Am J Hum Genet 60:80-6

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