Agency
National Institute of Health (NIH)
Institute
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Type
Research Project (R01)
Project #
5R01HD028154-03
Application #
2200911
Study Section
Reproductive Biology Study Section (REB)
Project Start
1992-02-01
Project End
1997-01-31
Budget Start
1994-02-01
Budget End
1997-01-31
Support Year
3
Fiscal Year
1994
Total Cost
Indirect Cost
Name
Cedars-Sinai Medical Center
Department
Type
DUNS #
075307785
City
Los Angeles
State
CA
Country
United States
Zip Code
90048
Zachow, R J; Weitsman, S R; Magoffin, D A (1997) Hepatocyte growth factor regulates ovarian theca-interstitial cell differentiation and androgen production. Endocrinology 138:691-7
Gelety, T J; Magoffin, D A (1997) Ontogeny of steroidogenic enzyme gene expression in ovarian theca-interstitial cells in the rat: regulation by a paracrine theca-differentiating factor prior to achieving luteinizing hormone responsiveness. Biol Reprod 56:938-45
Agarwal, S K; Judd, H L; Magoffin, D A (1996) A mechanism for the suppression of estrogen production in polycystic ovary syndrome. J Clin Endocrinol Metab 81:3686-91
Fournet, N; Weitsman, S R; Zachow, R J et al. (1996) Transforming growth factor-beta inhibits ovarian 17 alpha-hydroxylase activity by a direct noncompetitive mechanism. Endocrinology 137:166-74
Brzechffa, P R; Jakimiuk, A J; Agarwal, S K et al. (1996) Serum immunoreactive leptin concentrations in women with polycystic ovary syndrome. J Clin Endocrinol Metab 81:4166-9
Magarelli, P C; Zachow, R J; Magoffin, D A (1996) Developmental and hormonal regulation of rat theca-cell differentiation factor secretion in ovarian follicles. Biol Reprod 55:416-20
Magoffin, D A; Weitsman, S R (1994) Insulin-like growth factor-I regulation of luteinizing hormone (LH) receptor messenger ribonucleic acid expression and LH-stimulated signal transduction in rat ovarian theca-interstitial cells. Biol Reprod 51:766-75
Magoffin, D A; Weitsman, S R (1993) Insulin-like growth factor-I stimulates the expression of 3 beta-hydroxysteroid dehydrogenase messenger ribonucleic acid in ovarian theca-interstitial cells. Biol Reprod 48:1166-73
Magoffin, D A; Weitsman, S R (1993) Differentiation of ovarian theca-interstitial cells in vitro: regulation of 17 alpha-hydroxylase messenger ribonucleic acid expression by luteinizing hormone and insulin-like growth factor-I. Endocrinology 132:1945-51
Magoffin, D A; Weitsman, S R (1993) Effect of insulin-like growth factor-I on cholesterol side-chain cleavage cytochrome P450 messenger ribonucleic acid expression in ovarian theca-interstitial cells stimulated to differentiate in vitro. Mol Cell Endocrinol 96:45-51