Agency
National Institute of Health (NIH)
Institute
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Type
Research Project (R01)
Project #
5R01HD028187-06
Application #
2200944
Study Section
Pathobiochemistry Study Section (PBC)
Project Start
1991-05-01
Project End
1996-04-30
Budget Start
1995-05-01
Budget End
1996-04-30
Support Year
6
Fiscal Year
1995
Total Cost
Indirect Cost
Name
University of Illinois at Chicago
Department
Biochemistry
Type
Schools of Medicine
DUNS #
121911077
City
Chicago
State
IL
Country
United States
Zip Code
60612
Gettins, P G (1995) Thiol ester cleavage-dependent conformational change in human alpha 2-macroglobulin. Influence of attacking nucleophile and of Cys949 modification. Biochemistry 34:12233-40
Gettins, P G; Hahn, K H; Crews, B C (1995) Alpha 2-macroglobulin bait region variants. A role for the bait region in tetramer formation. J Biol Chem 270:14160-7
Gettins, P G; Crews, B; Beth, A H et al. (1995) Bait region-thiol ester mapping in human alpha 2-macroglobulin. FEBS Lett 367:137-40
Gettins, P G (1994) 1H- and 19F-NMR approaches to the study of the structure of proteins larger than 25 kDa. Int J Biol Macromol 16:227-35
Gettins, P G; Crews, B C (1994) Binding of epidermal growth factor to human alpha 2-macroglobulin. Significance for cytokine alpha 2-macroglobulin interactions. Ann N Y Acad Sci 737:383-98
Gettins, P G; Boel, E; Crews, B C (1994) Thiol ester role in correct folding and conformation of human alpha 2-macroglobulin. Properties of recombinant C949S variant. FEBS Lett 339:276-80
Gettins, P G; Crews, B C (1993) Human alpha 2-macroglobulin structure. Location of Cys-949 residues within a half-molecule measured by fluorescence energy transfer. FEBS Lett 332:211-4
Gettins, P G; Crews, B C (1993) Epidermal growth factor binding to human alpha 2-macroglobulin. Implications for alpha 2-macroglobulin-growth factor interactions. Biochemistry 32:7916-21
Gettins, P G; Beechem, J M; Crews, B C (1993) alpha 2-Macroglobulin bait region integrity. Role in determining fast-form structure. FEBS Lett 325:267-70