This application will test the hypothesis that during parturition glutamine is diverted from fetal hepatic glutamate output to glycogen synthesis. The proposed studies will examine by multiple tracer methodology the interrelationship between fetal hepatic glucose production and glutamine metabolism and glutamate release during spontaneous parturition, and during the stimulation of fetal hepatic gluconeogenesis by cortisol. Other experiments will examine the metabolic and physiologic impact of maintaining a high fetal glutamate supply to the placenta around the time of parturition.

Agency
National Institute of Health (NIH)
Institute
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Type
Research Project (R01)
Project #
5R01HD029374-06
Application #
2673685
Study Section
Human Embryology and Development Subcommittee 1 (HED)
Project Start
1992-08-01
Project End
1999-07-31
Budget Start
1998-08-01
Budget End
1999-07-31
Support Year
6
Fiscal Year
1998
Total Cost
Indirect Cost
Name
University of Colorado Denver
Department
Physiology
Type
Schools of Medicine
DUNS #
065391526
City
Aurora
State
CO
Country
United States
Zip Code
80045
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