Agency
National Institute of Health (NIH)
Institute
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Type
Research Project (R01)
Project #
5R01HD029894-03
Application #
2202258
Study Section
Reproductive Biology Study Section (REB)
Project Start
1993-08-01
Project End
1997-07-31
Budget Start
1995-08-01
Budget End
1997-07-31
Support Year
3
Fiscal Year
1995
Total Cost
Indirect Cost
Name
University of Cincinnati
Department
Anatomy/Cell Biology
Type
Schools of Medicine
DUNS #
City
Cincinnati
State
OH
Country
United States
Zip Code
45221
Nemade, Rashmi V; Carrette, Odile; Larsen, William J et al. (2002) Involvement of nitric oxide and the ovarian blood follicle barrier in murine follicular cyst development. Fertil Steril 78:1301-8
Jean, L; Mizon, C; Larsen, W J et al. (2001) Unmasking a hyaluronan-binding site of the BX(7)B type in the H3 heavy chain of the inter-alpha-inhibitor family. Eur J Biochem 268:544-53
Carrette, O; Nemade, R V; Day, A J et al. (2001) TSG-6 is concentrated in the extracellular matrix of mouse cumulus oocyte complexes through hyaluronan and inter-alpha-inhibitor binding. Biol Reprod 65:301-8
Mio, K; Carrette, O; Maibach, H I et al. (2000) Evidence that the serum inhibitor of hyaluronidase may be a member of the inter-alpha-inhibitor family. J Biol Chem 275:32413-21
Hess, K A; Chen, L; Larsen, W J (1999) Inter-alpha-inhibitor binding to hyaluronan in the cumulus extracellular matrix is required for optimal ovulation and development of mouse oocytes. Biol Reprod 61:436-43
Hess, K A; Chen, L; Larsen, W J (1998) The ovarian blood follicle barrier is both charge- and size-selective in mice. Biol Reprod 58:705-11
Larsen, W J; Chen, L; Powers, R et al. (1996) Cumulus expansion initiates physical and developmental autonomy of the oocyte. Zygote 4:335-41
Powers, R W; Chambers, C; Larsen, W J (1996) Diabetes-mediated decreases in ovarian superoxide dismutase activity are related to blood-follicle barrier and ovulation defects. Endocrinology 137:3101-10
Chen, L; Zhang, H; Powers, R W et al. (1996) Covalent linkage between proteins of the inter-alpha-inhibitor family and hyaluronic acid is mediated by a factor produced by granulosa cells. J Biol Chem 271:19409-14
Powers, R W; Chen, L; Russell, P T et al. (1995) Gonadotropin-stimulated regulation of blood-follicle barrier is mediated by nitric oxide. Am J Physiol 269:E290-8

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