Abstract

Four Hypotheses are proposed for investigation. Hypothesis 1. The kidneys from gravid rats have increased expression of NO synthase (NOS), which contributes to the NO-dependent renal vasodilation and hyperfiltration of pregnancy. Hypothesis 2. Increased activation of the endothelin (RES-701-1 antagonist sensitive) B receptor subtype located on the endothelium contributes to NO-dependent renal vasodilation and hyperfiltration in gravid rats. Hypothesis 3. Relaxin also contributes to NO-dependent renal vasodilation and hyperfiltration in gravid rats. Hypothesis 4. Relaxin contributes to renal vasodilation, hyperfiltration, and osmoregulatory changes in gravid women.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Type
Research Project (R01)
Project #
5R01HD030325-07
Application #
2889083
Study Section
Human Embryology and Development Subcommittee 1 (HED)
Program Officer
Ilekis, John V
Project Start
1998-04-20
Project End
2002-03-31
Budget Start
1999-04-01
Budget End
2000-03-31
Support Year
7
Fiscal Year
1999
Total Cost
Indirect Cost

  Institution

Name
Magee-Women's Hospital of Upmc
Department
Type
DUNS #
City
Pittsburgh
State
PA
Country
United States
Zip Code
15213

  Publications

Conrad, Kirk P; Davison, John M (2014) The renal circulation in normal pregnancy and preeclampsia: is there a place for relaxin? Am J Physiol Renal Physiol 306:F1121-35
Conrad, Kirk P (2011) Maternal vasodilation in pregnancy: the emerging role of relaxin. Am J Physiol Regul Integr Comp Physiol 301:R267-75
Conrad, Kirk P; Shroff, Sanjeev G (2011) Effects of relaxin on arterial dilation, remodeling, and mechanical properties. Curr Hypertens Rep 13:409-20
Conrad, Kirk P (2011) Emerging role of relaxin in the maternal adaptations to normal pregnancy: implications for preeclampsia. Semin Nephrol 31:15-32
Conrad, Kirk P (2010) Unveiling the vasodilatory actions and mechanisms of relaxin. Hypertension 56:2-9
McGuane, Jonathan T; Debrah, Julianna E; Debrah, Dan O et al. (2009) Role of relaxin in maternal systemic and renal vascular adaptations during gestation. Ann N Y Acad Sci 1160:304-12
Jeyabalan, Arundhathi; Shroff, Sanjeev G; Novak, Jaqueline et al. (2007) The vascular actions of relaxin. Adv Exp Med Biol 612:65-87
Jeyabalan, Arundhathi; Conrad, Kirk P (2007) Renal function during normal pregnancy and preeclampsia. Front Biosci 12:2425-37
Conrad, Kirk P; Jeyabalan, Arun; Danielson, Leslie A et al. (2005) Role of relaxin in maternal renal vasodilation of pregnancy. Ann N Y Acad Sci 1041:147-54
Conrad, K P; Novak, J; Danielson, L A et al. (2005) Mechanisms of renal vasodilation and hyperfiltration during pregnancy: current perspectives and potential implications for preeclampsia. Endothelium 12:57-62

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