Agency
National Institute of Health (NIH)
Institute
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Type
Research Project (R01)
Project #
5R01HD031840-03
Application #
2204613
Study Section
Special Emphasis Panel (SRC (05))
Project Start
1994-05-01
Project End
1999-04-30
Budget Start
1996-05-01
Budget End
1997-04-30
Support Year
3
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Children's Memorial Hospital (Chicago)
Department
Type
DUNS #
City
Chicago
State
IL
Country
United States
Zip Code
60611
Hsueh, Wei; Caplan, Michael S; Qu, Xiao-Wu et al. (2003) Neonatal necrotizing enterocolitis: clinical considerations and pathogenetic concepts. Pediatr Dev Pathol 6:6-23
De Plaen, Isabelle G; Qu, Xiao-Wu; Wang, Hao et al. (2002) Endotoxin, but not platelet-activating factor, activates nuclear factor-kappaB and increases IkappaBalpha and IkappaBbeta turnover in enterocytes. Immunology 106:577-83
Tan, X D; Chang, H; Qu, X W et al. (2000) Platelet-activating factor increases mucosal permeability in rat intestine via tyrosine phosphorylation of E-cadherin. Br J Pharmacol 129:1522-9
De Plaen, I G; Tan, X D; Chang, H et al. (2000) Lipopolysaccharide activates nuclear factor kappaB in rat intestine: role of endogenous platelet-activating factor and tumour necrosis factor. Br J Pharmacol 129:307-14
Qu, X W; Rozenfeld, R A; Huang, W et al. (1999) The role of xanthine oxidase in platelet activating factor induced intestinal injury in the rat. Gut 44:203-11
Qu, X W; Rozenfeld, R A; Huang, W et al. (1999) Roles of nitric oxide synthases in platelet-activating factor-induced intestinal necrosis in rats. Crit Care Med 27:356-64
Qu, X W; Wang, H; Rozenfeld, R A et al. (1999) Type I nitric oxide synthase (NOS) is the predominant NOS in rat small intestine. Regulation by platelet-activating factor. Biochim Biophys Acta 1451:211-7
Tan, X D; Liu, Q P; Hsueh, W et al. (1999) Intestinal trefoil factor binds to intestinal epithelial cells and induces nitric oxide production: priming and enhancing effects of mucin. Biochem J 338 ( Pt 3):745-51
Wang, H; Tan, X; Chang, H et al. (1999) Platelet-activating factor receptor mRNA is localized in eosinophils and epithelial cells in rat small intestine: regulation by dexamethasone and gut flora. Immunology 97:447-54
Hsueh, W; Caplan, M S; Tan, X et al. (1998) Necrotizing enterocolitis of the newborn: pathogenetic concepts in perspective. Pediatr Dev Pathol 1:2-16

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