Abstract

An integrated, behavior-genetic analysis of learning and memory processes in Drosophila is being pursued. Behavioral assays that reliably quantify several properties of non-associative and associative learning and memory formation have been developed. Initial results have revealed substantial functional similarities between fruit flies and vertebrates for these behavioral properties. Continuation of this work is organized along the following goals: 1. Behavior-genetic analyses of memory formation 2. Behavior-genetic analyses of associative learning 3. Behavior-genetic analyses of non-associative learning 4. Anatomy and development of learning and memory 5. Analyses of sensorimotor controls

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Type
Research Project (R01)
Project #
2R01HD032245-04
Application #
2025583
Study Section
Special Emphasis Panel (ZRG2-GEN (03))
Project Start
1994-04-01
Project End
2002-03-31
Budget Start
1997-04-09
Budget End
1998-03-31
Support Year
4
Fiscal Year
1997
Total Cost
Indirect Cost

  Institution

Name
Cold Spring Harbor Laboratory
Department
Type
DUNS #
065968786
City
Cold Spring Harbor
State
NY
Country
United States
Zip Code
11724

  Publications

Pendleton, Robert G; Rasheed, Aseel; Sardina, Thomas et al. (2002) Effects of tyrosine hydroxylase mutants on locomotor activity in Drosophila: a study in functional genomics. Behav Genet 32:89-94
Connolly, J B; Tully, T (1998) Integrins: a role for adhesion molecules in olfactory memory. Curr Biol 8:R386-9
Goodwin, S F; Del Vecchio, M; Velinzon, K et al. (1997) Defective learning in mutants of the Drosophila gene for a regulatory subunit of cAMP-dependent protein kinase. J Neurosci 17:8817-27
Mihalek, R M; Jones, C J; Tully, T (1997) The Drosophila mutation turnip has pleiotropic behavioral effects and does not specifically affect learning. Learn Mem 3:425-44
Connolly, J B; Roberts, I J; Armstrong, J D et al. (1996) Associative learning disrupted by impaired Gs signaling in Drosophila mushroom bodies. Science 274:2104-7
Yin, J C; Tully, T (1996) CREB and the formation of long-term memory. Curr Opin Neurobiol 6:264-8
Tully, T; Bolwig, G; Christensen, J et al. (1996) A return to genetic dissection of memory in Drosophila. Cold Spring Harb Symp Quant Biol 61:207-18
DeZazzo, J; Tully, T (1995) Dissection of memory formation: from behavioral pharmacology to molecular genetics. Trends Neurosci 18:212-8
Yin, J C; Del Vecchio, M; Zhou, H et al. (1995) CREB as a memory modulator: induced expression of a dCREB2 activator isoform enhances long-term memory in Drosophila. Cell 81:107-15
Yin, J C; Wallach, J S; Del Vecchio, M et al. (1994) Induction of a dominant negative CREB transgene specifically blocks long-term memory in Drosophila. Cell 79:49-58

Showing the most recent 10 out of 11 publications