Preeclampsia, the third leading cause of maternal mortality in the United States, is an important cause of preterm delivery, fetal growth retardation, and perinatal mortality. Uteroplacental hypoperfusion is thought to be the primary defect in preeclampsia. Endothelial cell damage is also important in the pathogenesis of preeclampsia. Previous investigators have focused on the cause of these vascular insults. Findings from several disciplines indicate that preeclampsia is associated with excessive lipid peroxidation, oxidant-antioxidant imbalance, as well as an imbalance in n-3 and n-6 polyunsaturated fatty acids, and in thrombooxane and prostacyclin synthesis. Presently it is unknown whether these features precede preeclampsia or are secondary to the disease process. The authors propose to conduct a prospective cohort study of pregnant nulliparous women. The overall aim of the proposed research is to evaluate whether, and to what extent, maternal intake of dietary marine fatty acids and antioxidant vitamins are associated with risk of preeclampsia. The authors will collect maternal blood and urine specimens from a cohort of 1500 women during the first trimester of pregnancy. At the same time, information regarding medical and behavioral characteristics will be collected by interview. Medical records will be reviewed in order to collect information regarding pregnancy outcome. Blood and urine specimens will be processed and stored at -70C until analysis. Maternal intake of marine fatty acids and antioxidant vitamins will be assessed using biochemical and dietary methods. Eicosanoids and indicators of lipid peroxidation will also be evaluated. Using a nested case-cohort sampling design, the authors will identify 90 women with preeclampsia and an equal number of women with gestational hypertension. One hundred and fifty women randomly selected from the entire study cohort (N- 1500) will serve as a single reference group for all individuals sampled. Statistical analyses will focus on determining: (1) the extent to which lipid peroxidation and eicosanoid synthesis in the first trimester are associated with subsequent risk of preeclampsia and gestational hypertension, respectively; and (2) whether these metabolic factors are associated with maternal diet. The investigators state that clinical applications of study findings may result in early identification of women at risk of preeclampsia and an effective intervention.

Agency
National Institute of Health (NIH)
Institute
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Type
Research Project (R01)
Project #
5R01HD032562-04
Application #
2889149
Study Section
Epidemiology and Disease Control Subcommittee 2 (EDC)
Program Officer
Catz, Charlotte S
Project Start
1996-06-01
Project End
2001-05-31
Budget Start
1999-06-01
Budget End
2000-05-31
Support Year
4
Fiscal Year
1999
Total Cost
Indirect Cost
Name
Swedish Medical Center, First Hill
Department
Type
DUNS #
City
Seattle
State
WA
Country
United States
Zip Code
98122
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Badon, Sylvia E; Enquobahrie, Daniel A; Wartko, Paige D et al. (2017) Healthy Lifestyle During Early Pregnancy and Risk of Gestational Diabetes Mellitus. Am J Epidemiol 186:326-333
Qiu, Chunfang; Lawrence, Wayne; Gelaye, Bizu et al. (2017) Risk of glucose intolerance and gestational diabetes mellitus in relation to maternal habitual snoring during early pregnancy. PLoS One 12:e0184966
Enquobahrie, Daniel A; Wander, Pandora L; Tadesse, Mahlet G et al. (2017) Maternal pre-pregnancy body mass index and circulating microRNAs in pregnancy. Obes Res Clin Pract 11:464-474
Osorio-Yáñez, Citlalli; Qiu, Chunfang; Gelaye, Bizu et al. (2017) Risk of gestational diabetes mellitus in relation to maternal dietary calcium intake. Public Health Nutr 20:1082-1089
Ncube, Collette N; Gavin, Amelia R; Williams, Michelle A et al. (2017) Sex-specific associations of maternal birthweight with offspring birthweight in the Omega study. Ann Epidemiol 27:308-314.e4
Wander, Pandora L; Boyko, Edward J; Hevner, Karin et al. (2017) Circulating early- and mid-pregnancy microRNAs and risk of gestational diabetes. Diabetes Res Clin Pract 132:1-9
Workalemahu, Tsegaselassie; Badon, Sylvia E; Dishi-Galitzky, Michal et al. (2017) Placental genetic variations in vitamin D metabolism and birthweight. Placenta 50:78-83
Badon, Sylvia E; Littman, Alyson J; Chan, Kwun Chuen Gary et al. (2017) Trajectories of maternal leisure-time physical activity and sedentary behavior during adolescence to young adulthood and offspring birthweight. Ann Epidemiol 27:701-707.e3

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