Agency
National Institute of Health (NIH)
Institute
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Type
Research Project (R01)
Project #
1R01HD033907-01A1
Application #
2207464
Study Section
Reproductive Endocrinology Study Section (REN)
Project Start
1996-08-02
Project End
1999-07-31
Budget Start
1996-08-02
Budget End
1997-07-31
Support Year
1
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Cedars-Sinai Medical Center
Department
Type
DUNS #
075307785
City
Los Angeles
State
CA
Country
United States
Zip Code
90048
Munir, Iqbal; Yen, Hui-Wen; Baruth, Talia et al. (2005) Resistin stimulation of 17alpha-hydroxylase activity in ovarian theca cells in vitro: relevance to polycystic ovary syndrome. J Clin Endocrinol Metab 90:4852-7
Daneshmand, Said; Weitsman, Stacy R; Navab, Alireza et al. (2002) Overexpression of theca-cell messenger RNA in polycystic ovary syndrome does not correlate with polymorphisms in the cholesterol side-chain cleavage and 17alpha-hydroxylase/C(17-20) lyase promoters. Fertil Steril 77:274-80
Jakimiuk, Artur J; Weitsman, Stacy R; Yen, Hui-Wen et al. (2002) Estrogen receptor alpha and beta expression in theca and granulosa cells from women with polycystic ovary syndrome. J Clin Endocrinol Metab 87:5532-8
Jakimiuk, A J; Weitsman, S R; Navab, A et al. (2001) Luteinizing hormone receptor, steroidogenesis acute regulatory protein, and steroidogenic enzyme messenger ribonucleic acids are overexpressed in thecal and granulosa cells from polycystic ovaries. J Clin Endocrinol Metab 86:1318-23
Magoffin, D A; Weitsman, S R; Aagarwal, S K et al. (1999) Leptin regulation of aromatase activity in adipose stromal cells from regularly cycling women. Ginekol Pol 70:1-7
Agarwal, S K; Vogel, K; Weitsman, S R et al. (1999) Leptin antagonizes the insulin-like growth factor-I augmentation of steroidogenesis in granulosa and theca cells of the human ovary. J Clin Endocrinol Metab 84:1072-6
Zachow, R J; Weitsman, S R; Magoffin, D A (1999) Leptin impairs the synergistic stimulation by transforming growth factor-beta of follicle-stimulating hormone-dependent aromatase activity and messenger ribonucleic acid expression in rat ovarian granulosa cells. Biol Reprod 61:1104-9
Jakimiuk, A J; Weitsman, S R; Magoffin, D A (1999) 5alpha-reductase activity in women with polycystic ovary syndrome. J Clin Endocrinol Metab 84:2414-8
Shimon, I; Yan, X; Magoffin, D A et al. (1998) Intact leptin receptor is selectively expressed in human fetal pituitary and pituitary adenomas and signals human fetal pituitary growth hormone secretion. J Clin Endocrinol Metab 83:4059-64
Jakimiuk, A J; Weitsman, S R; Brzechffa, P R et al. (1998) Aromatase mRNA expression in individual follicles from polycystic ovaries. Mol Hum Reprod 4:1-8

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