Agency
National Institute of Health (NIH)
Institute
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Type
Research Project (R01)
Project #
1R01HD034032-01
Application #
2207586
Study Section
Biochemical Endocrinology Study Section (BCE)
Project Start
1996-05-01
Project End
2000-04-30
Budget Start
1996-05-01
Budget End
1997-04-30
Support Year
1
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Case Western Reserve University
Department
Pharmacology
Type
Schools of Medicine
DUNS #
077758407
City
Cleveland
State
OH
Country
United States
Zip Code
44106
Nilson, J H; Abbud, R A; Keri, R A et al. (2000) Chronic hypersecretion of luteinizing hormone in transgenic mice disrupts both ovarian and pituitary function, with some effects modified by the genetic background. Recent Prog Horm Res 55:69-89; discussion 89-91
Kero, J; Poutanen, M; Zhang, F P et al. (2000) Elevated luteinizing hormone induces expression of its receptor and promotes steroidogenesis in the adrenal cortex. J Clin Invest 105:633-41
Keri, R A; Lozada, K L; Abdul-Karim, F W et al. (2000) Luteinizing hormone induction of ovarian tumors: oligogenic differences between mouse strains dictates tumor disposition. Proc Natl Acad Sci U S A 97:383-7
Abbud, R A; Ameduri, R K; Rao, J S et al. (1999) Chronic hypersecretion of luteinizing hormone in transgenic mice selectively alters responsiveness of the alpha-subunit gene to gonadotropin-releasing hormone and estrogens. Mol Endocrinol 13:1449-59
Mann, R J; Keri, R A; Nilson, J H (1999) Transgenic mice with chronically elevated luteinizing hormone are infertile due to anovulation, defects in uterine receptivity, and midgestation pregnancy failure. Endocrinology 140:2592-601
Flaws, J A; Abbud, R; Mann, R J et al. (1997) Chronically elevated luteinizing hormone depletes primordial follicles in the mouse ovary. Biol Reprod 57:1233-7
Risma, K A; Hirshfield, A N; Nilson, J H (1997) Elevated luteinizing hormone in prepubertal transgenic mice causes hyperandrogenemia, precocious puberty, and substantial ovarian pathology. Endocrinology 138:3540-7