Two questions to be addressed in this application are: how are class II genes controlled in the developing fetus and what happens when class II genes are expressed at different times during gestation? Experiments are designed to 1) determine the molecular mechanism of regulation by examining class II specific transcription factors and promoter occupancy in fetal tissues, 2) identify cytokines that regulate class II expression on fetal tissues, 3) determine the effects of fetal or maternal class II expression during gestation by creating transgenic mice that will carry an inducible global regulator of class II gene expression.

Agency
National Institute of Health (NIH)
Institute
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Type
Research Project (R01)
Project #
5R01HD034440-05
Application #
6181835
Study Section
Human Embryology and Development Subcommittee 1 (HED)
Program Officer
Lock, Allan
Project Start
1996-09-15
Project End
2002-08-31
Budget Start
2000-09-01
Budget End
2002-08-31
Support Year
5
Fiscal Year
2000
Total Cost
$273,372
Indirect Cost
Name
Emory University
Department
Microbiology/Immun/Virology
Type
Schools of Medicine
DUNS #
066469933
City
Atlanta
State
GA
Country
United States
Zip Code
30322