The hypothesis to be tested is that restricted availability of metabolic/nutritional substrates in utero in animals with IUGR at birth induces insulin and IGF resistance during both pre- and postnatal periods. It is proposed that such an effect contributes to retarded growth in utero and persistence of the metabolic derangements postnatally. The investigator plans to use the maternal dietary restriction IUGR rat model to study the changes in the insulin/IGF signaling which occur in these animals in pre- and postnatal periods in order to understand the underlying mechanism.

Agency
National Institute of Health (NIH)
Institute
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Type
Research Project (R01)
Project #
5R01HD035831-03
Application #
6363408
Study Section
Human Embryology and Development Subcommittee 1 (HED)
Program Officer
Ilekis, John V
Project Start
1999-03-17
Project End
2003-02-28
Budget Start
2001-03-01
Budget End
2002-02-28
Support Year
3
Fiscal Year
2001
Total Cost
$152,807
Indirect Cost
Name
Rhode Island Hospital (Providence, RI)
Department
Type
DUNS #
161202122
City
Providence
State
RI
Country
United States
Zip Code
02903
Sanders, Jennifer A; Schorl, Christoph; Patel, Ajay et al. (2012) Postnatal liver growth and regeneration are independent of c-myc in a mouse model of conditional hepatic c-myc deletion. BMC Physiol 12:1
Gruppuso, Philip A; Boylan, Joan M; Sanders, Jennifer A (2011) The physiology and pathophysiology of rapamycin resistance: implications for cancer. Cell Cycle 10:1050-8
Jimenez, Rosa H; Lee, Ju-Seog; Francesconi, Mirko et al. (2010) Regulation of gene expression in hepatic cells by the mammalian Target of Rapamycin (mTOR). PLoS One 5:e9084
Jimenez, Rosa H; Boylan, Joan M; Lee, Ju-Seog et al. (2009) Rapamycin response in tumorigenic and non-tumorigenic hepatic cell lines. PLoS One 4:e7373
Kim, Mimi S; Wu, Ke Ying; Auyeung, Valerie et al. (2009) Leucine restriction inhibits chondrocyte proliferation and differentiation through mechanisms both dependent and independent of mTOR signaling. Am J Physiol Endocrinol Metab 296:E1374-82
Phornphutkul, Chanika; Lee, Mark; Voigt, Cliff et al. (2009) The effect of rapamycin on bone growth in rabbits. J Orthop Res 27:1157-61
Phornphutkul, Chanika; Wu, Ke-Ying; Auyeung, Valerie et al. (2008) mTOR signaling contributes to chondrocyte differentiation. Dev Dyn 237:702-12
Gruppuso, Philip A; Tsai, Shu-Whei; Boylan, Joan M et al. (2008) Hepatic translation control in the late-gestation fetal rat. Am J Physiol Regul Integr Comp Physiol 295:R558-67
Sanders, Jennifer A; Lakhani, Alisha; Phornphutkul, Chanika et al. (2008) The effect of rapamycin on DNA synthesis in multiple tissues from late gestation fetal and postnatal rats. Am J Physiol Cell Physiol 295:C406-13
Yoo, Sunny J-S; Jimenez, Rosa H; Sanders, Jennifer A et al. (2008) The alpha4-containing form of protein phosphatase 2A in liver and hepatic cells. J Cell Biochem 105:290-300

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