Abstract

This proposal intends to follow a group of 117 adolescents with ADHD and a comparable control group for as well as over 100 of their siblings, subjects already followed for five years, for an additional five years. Given the mean age of the sample, this study will provide information about ADHD as subjects mature from adolescence into young adult life. These subjects will be assessed on six domains: psychopathology, cognitive-neuropsychological functioning, school dysfunction, adaptive functioning, treatment interventions and psychosocial adversity. A variety of measures are included in the assessment of each domain. Analytic methods address six issues: variable age of onset of psychiatric illness; nonindependence of observations within families and between time periods; effects of treatment; integration of information across multiple informants; effects of confounding variables; wide age range of the sample at baseline. The investigators will test three general hypotheses: prediction of outcome based on baseline ADHD (or sibling of ADHD); prediction of outcome based on comorbidity; prediction of outcome and comorbidity based on DSM-IV subtypes.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Type
Research Project (R01)
Project #
5R01HD036317-02
Application #
2889490
Study Section
Human Development and Aging Subcommittee 3 (HUD)
Program Officer
Haverkos, Lynne
Project Start
1998-04-01
Project End
2003-03-31
Budget Start
1999-04-01
Budget End
2000-03-31
Support Year
2
Fiscal Year
1999
Total Cost
Indirect Cost

  Institution

Name
Massachusetts General Hospital
Department
Type
DUNS #
City
Boston
State
MA
Country
United States
Zip Code
02199

  Publications

Uchida, Mai; Fitzgerald, Maura; Woodworth, Hilary et al. (2018) Subsyndromal Manifestations of Depression in Children Predict the Development of Major Depression. J Pediatr 201:252-258.e1
Yule, Amy M; Wilens, Timothy E; Martelon, MaryKate et al. (2018) Does exposure to parental substance use disorders increase offspring risk for a substance use disorder? A longitudinal follow-up study into young adulthood. Drug Alcohol Depend 186:154-158
Biederman, Joseph; Fitzgerald, Maura; Woodworth, K Yvonne et al. (2018) Does the course of manic symptoms in pediatric bipolar disorder impact the course of conduct disorder? Findings from four prospective datasets. J Affect Disord 238:244-249
Wozniak, Janet; Uchida, Mai; Faraone, Stephen V et al. (2017) Similar familial underpinnings for full and subsyndromal pediatric bipolar disorder: A familial risk analysis. Bipolar Disord 19:168-175
Yule, Amy M; Martelon, MaryKate; Faraone, Stephen V et al. (2017) Examining the association between attention deficit hyperactivity disorder and substance use disorders: A familial risk analysis. J Psychiatr Res 85:49-55
Mattfeld, Aaron T; Whitfield-Gabrieli, Susan; Biederman, Joseph et al. (2016) Dissociation of working memory impairments and attention-deficit/hyperactivity disorder in the brain. Neuroimage Clin 10:274-82
Fried, Ronna; Chan, James; Feinberg, Leah et al. (2016) Clinical correlates of working memory deficits in youth with and without ADHD: A controlled study. J Clin Exp Neuropsychol 38:487-96
Chai, Xiaoqian J; Hirshfeld-Becker, Dina; Biederman, Joseph et al. (2015) Functional and structural brain correlates of risk for major depression in children with familial depression. Neuroimage Clin 8:398-407
Biederman, Joseph; Feinberg, Leah; Chan, James et al. (2015) Mild Traumatic Brain Injury and Attention-Deficit Hyperactivity Disorder in Young Student Athletes. J Nerv Ment Dis 203:813-9
Biederman, Joseph; Petty, Carter; Spencer, Thomas J et al. (2014) Is ADHD a risk for posttraumatic stress disorder (PTSD)? Results from a large longitudinal study of referred children with and without ADHD. World J Biol Psychiatry 15:49-55

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