Abstract

The hypothesis to be tested is that during pregnancy the relationship between RIHP and sodium excretion becomes gradually attenuated due to a gradual increase in the compliance of the renal interstitium. The combination of increased renal interstitial compliance and reduced natriuretic sensitivity to increases in RIHP leads to an attenuated increase in RIHP and less sodium excretion and the gradual volume retention and progressive volume expansion during the course of pregnancy. The proposed studies will determine the relationship between renal perfusion pressure (RPP), RIHP, and sodium excretion in pregnancy. Also, the compliance of the renal interstitium and the sensitivity of the natriuretic response will be determined with selective increases in RHIP by direct renal interstitial volume expansion (DRIVE) utilizing a chronically implanted polyethylene matrix in the left kidney.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Type
Research Project (R01)
Project #
5R01HD038240-03
Application #
6388180
Study Section
Human Embryology and Development Subcommittee 1 (HED)
Program Officer
Spong, Catherine
Project Start
2000-05-01
Project End
2004-04-30
Budget Start
2001-05-01
Budget End
2002-04-30
Support Year
3
Fiscal Year
2001
Total Cost
$184,280
Indirect Cost

  Institution

Name
Eastern Virginia Medical School
Department
Physiology
Type
Schools of Medicine
DUNS #
City
Norfolk
State
VA
Country
United States
Zip Code
23501

  Publications

Yu, Tianzheng; Khraibi, Ali A (2008) Enalapril treatment restores the decreased proximal tubule reabsorption in response to acute volume expansion in diabetic rats. Life Sci 83:364-8
Yu, Tianzheng; Khraibi, Ali A (2006) Renal interstitial hydrostatic pressure and natriuretic response to high doses of angiotensin II in pregnant rats. Am J Hypertens 19:300-5
Khraibi, Ali A; Dobrian, Anca D; Yu, Tianzheng et al. (2005) Role of RIHP and renal tubular sodium transporters in volume retention of pregnant rats. Am J Hypertens 18:1375-83
Yu, Tianzheng; Khraibi, Ali A (2005) Natriuretic response to direct renal interstitial volume expansion (DRIVE) in pregnant rats. Am J Hypertens 18:851-7
Dobrian, Anca D; Schriver, Suzanne D; Khraibi, Ali A et al. (2004) Pioglitazone prevents hypertension and reduces oxidative stress in diet-induced obesity. Hypertension 43:48-56
Tang, Daiyi; Yu, Tianzheng; Khraibi, Ali A (2004) Cardiovascular and renal characteristics, and responses to acute volume expansion of a rat model of diabetic pregnancy. Life Sci 74:2909-18
Khraibi, Ali A; Yu, Tianzheng; Tang, Daiyi (2003) Role of nitric oxide in the natriuretic and diuretic responses in pregnant rats. Am J Physiol Renal Physiol 285:F938-44
Khraibi, Ali A (2002) Renal interstitial hydrostatic pressure and sodium excretion in hypertension and pregnancy. J Hypertens Suppl 20:S21-7
Khraibi, Ali A; Solhaug, Michael J; Dobrian, Anca D et al. (2002) Renal interstitial hydrostatic pressure and natriuretic responses to volume expansion in pregnant rats. Am J Physiol Renal Physiol 282:F821-5
Khraibi, A A; Liang, M; Berndt, T J (2001) Role of gender on renal interstitial hydrostatic pressure and sodium excretion in rats. Am J Hypertens 14:893-6

Showing the most recent 10 out of 12 publications