Abstract

The goal of this study is to determine the roles of nitric oxide (NO) and its possible relationship with the intracellular Ca2+ transients in the processes of oocyte activation and cell cycle. The possible role of NO in regulating the egg's ion channels (as part of polyspermy block) and sperm physiology (such as motility and the acrosome reaction) will also be investigated.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Type
Research Project (R01)
Project #
5R01HD038488-02
Application #
6351424
Study Section
Reproductive Biology Study Section (REB)
Program Officer
Tasca, Richard J
Project Start
2000-02-01
Project End
2003-01-31
Budget Start
2001-02-01
Budget End
2002-01-31
Support Year
2
Fiscal Year
2001
Total Cost
$209,579
Indirect Cost

  Institution

Name
Stanford University
Department
Biology
Type
Schools of Arts and Sciences
DUNS #
800771545
City
Stanford
State
CA
Country
United States
Zip Code
94305

  Publications

Patton, Chris; Thompson, Stuart; Epel, David (2004) Some precautions in using chelators to buffer metals in biological solutions. Cell Calcium 35:427-31
Thaler, Catherine D; Kuo, Richard C; Patton, Chris et al. (2004) Phosphoinositide metabolism at fertilization of sea urchin eggs measured with a GFP-probe. Dev Growth Differ 46:413-23
Thaler, Catherine D; Epel, David (2003) Nitric oxide in oocyte maturation, ovulation, fertilization, cleavage and implantation: a little dab'll do ya. Curr Pharm Des 9:399-409