Abstract

Using a well characterized and established murine model of HSC transplantation into fetuses, the research team will determine the role of the ontogeny of both stem cells and hematopoietic micro-environment on donor cell engraftment. The relative dominance of each will then be assessed. Then, the role of the immune system and the effects it mediates on transplanted hematopoietic stem cells will be examined.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Type
Research Project (R01)
Project #
5R01HD039251-03
Application #
6536179
Study Section
Human Embryology and Development Subcommittee 1 (HED)
Program Officer
Lock, Allan
Project Start
2000-08-01
Project End
2005-05-31
Budget Start
2002-06-01
Budget End
2003-05-31
Support Year
3
Fiscal Year
2002
Total Cost
$305,775
Indirect Cost

  Institution

Name
Oregon Health and Science University
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
009584210
City
Portland
State
OR
Country
United States
Zip Code
97239

  Publications

Bailey, Alexis S; Jiang, Shuguang; Afentoulis, Michael et al. (2004) Transplanted adult hematopoietic stems cells differentiate into functional endothelial cells. Blood 103:13-9
Jiang, Shuguang; Walker, Luke; Afentoulis, Michael et al. (2004) Transplanted human bone marrow contributes to vascular endothelium. Proc Natl Acad Sci U S A 101:16891-6
Baumann, Christina I; Bailey, Alexis S; Li, Weiming et al. (2004) PECAM-1 is expressed on hematopoietic stem cells throughout ontogeny and identifies a population of erythroid progenitors. Blood 104:1010-6