Abstract

The proposed project will bring together a broad team of bioengineers, neuroscientists, molecular biologists, bioinformaticists and clinical scientists to examine the molecular etiology of traumatic brain injury (TBI). The focus will be to study the genomic and protein expression of force transmission in the CNS, with the long term goal of treating and preventing neuronal necrosis and apoptosis in gray matter contusions, the most common form of damage in brain injured patients.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Type
Research Project (R01)
Project #
5R01HD041699-05
Application #
6934582
Study Section
Special Emphasis Panel (ZRG1-SSS-R (01))
Program Officer
Nitkin, Ralph M
Project Start
2001-08-03
Project End
2007-07-31
Budget Start
2005-08-01
Budget End
2007-07-31
Support Year
5
Fiscal Year
2005
Total Cost
$695,778
Indirect Cost

  Institution

Name
University of Pennsylvania
Department
Biomedical Engineering
Type
Schools of Engineering
DUNS #
042250712
City
Philadelphia
State
PA
Country
United States
Zip Code
19104

  Publications

Patel, Tapan P; Ventre, Scott C; Geddes-Klein, Donna et al. (2014) Single-neuron NMDA receptor phenotype influences neuronal rewiring and reintegration following traumatic injury. J Neurosci 34:4200-13
Singh, Pallab; Doshi, Shachee; Spaethling, Jennifer M et al. (2012) N-methyl-D-aspartate receptor mechanosensitivity is governed by C terminus of NR2B subunit. J Biol Chem 287:4348-59
Spaethling, Jennifer; Le, Linda; Meaney, David F (2012) NMDA receptor mediated phosphorylation of GluR1 subunits contributes to the appearance of calcium-permeable AMPA receptors after mechanical stretch injury. Neurobiol Dis 46:646-54
von Reyn, Catherine R; Mott, Rosalind E; Siman, Robert et al. (2012) Mechanisms of calpain mediated proteolysis of voltage gated sodium channel ?-subunits following in vitro dynamic stretch injury. J Neurochem 121:793-805
Mesfin, Mahlet N; von Reyn, Catherine R; Mott, Rosalind E et al. (2012) In vitro stretch injury induces time- and severity-dependent alterations of STEP phosphorylation and proteolysis in neurons. J Neurotrauma 29:1982-98
Choo, Anthony M; Geddes-Klein, Donna M; Hockenberry, Adam et al. (2012) NR2A and NR2B subunits differentially mediate MAP kinase signaling and mitochondrial morphology following excitotoxic insult. Neurochem Int 60:506-16
Meaney, David F; Smith, Douglas H (2011) Biomechanics of concussion. Clin Sports Med 30:19-31, vii
Singh, Pallab; Hockenberry, Adam J; Tiruvadi, Vineet R et al. (2011) Computational investigation of the changing patterns of subtype specific NMDA receptor activation during physiological glutamatergic neurotransmission. PLoS Comput Biol 7:e1002106
Creed, Jennifer A; DiLeonardi, Ann Mae; Fox, Douglas P et al. (2011) Concussive brain trauma in the mouse results in acute cognitive deficits and sustained impairment of axonal function. J Neurotrauma 28:547-63
Saatman, Kathryn E; Creed, Jennifer; Raghupathi, Ramesh (2010) Calpain as a therapeutic target in traumatic brain injury. Neurotherapeutics 7:31-42

Showing the most recent 10 out of 23 publications