While it is well-known that antisocial behavior runs in families, surprisingly little is known about the specific mechanisms by which it is transmitted from one generation to the next. While the intergenerational transmission paradigm is becoming increasingly influential in addressing this issue, very few such studies are prospective, include both parents, focus on early mechanisms, and address female as well as male antisocial behavior. Importantly, none to date have examined biological influences on transgenerational continuity and change, or how they interact with social factors in modulating the transmission of antisocial behavior. The proposed three-generation study attempts to address these gaps in knowledge by capitalizing on a novel design in which I ,795 males and females were tested on psychophysiological, behavioral, nutritional, and cognitive measures at age 3, while their first-generation parents were assessed on psychosocial influences. These second-generation three-year-olds are now aged 30 years and will be retested, together with their third-generation three-year-old offspring, on psychophysiological, psychosocial, cognitive, behavioral, parenting, and antisocial behavior measures. Both the second generation parent and their previously untested spouse will be tested on psychophysiological measures, together with measures of life stress, daily hassles, family conflict, mental illness, and criminal behavior. The study will also assess whether a nutritional, exercise, and educational enrichment from ages 3-5 years in 100 of the second generation subjects, which has lead to increased physiological arousal and attention at age 11 years and reduced conduct disorder at age 17 years, disrupts the intergenerational transmission of antisocial behavior from the second to third generations. It is thought that the study offers a truly unique opportunity to understand the unexplored issue of how biological influences interact with social contexts in either blocking or facilitating the intergenerational transmission of antisocial and aggressive behavior. This new knowledge, if further developed, could contribute to a new generation of more effective prevention programs for reducing antisocial and violent behavior.

Agency
National Institute of Health (NIH)
Institute
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Type
Research Project (R01)
Project #
1R01HD042259-01
Application #
6358686
Study Section
Special Emphasis Panel (ZRG1-RPHB-1 (01))
Program Officer
Oliveri, Mary Ellen
Project Start
2001-09-18
Project End
2006-06-30
Budget Start
2001-09-18
Budget End
2002-06-30
Support Year
1
Fiscal Year
2001
Total Cost
$568,772
Indirect Cost
Name
University of Southern California
Department
Psychology
Type
Schools of Arts and Sciences
DUNS #
041544081
City
Los Angeles
State
CA
Country
United States
Zip Code
90089
Yang, Yaling; Raine, Adrian; Colletti, Patrick et al. (2011) Abnormal structural correlates of response perseveration in individuals with psychopathy. J Neuropsychiatry Clin Neurosci 23:107-10
Yang, Yaling; Raine, Adrian; Han, Chen-Bo et al. (2010) Reduced hippocampal and parahippocampal volumes in murderers with schizophrenia. Psychiatry Res 182:9-13
Yang, Yaling; Raine, Adrian; Colletti, Patrick et al. (2010) Morphological alterations in the prefrontal cortex and the amygdala in unsuccessful psychopaths. J Abnorm Psychol 119:546-54
Gao, Yu; Raine, Adrian (2009) P3 event-related potential impairments in antisocial and psychopathic individuals: a meta-analysis. Biol Psychol 82:199-210
Yang, Yaling; Raine, Adrian (2009) Prefrontal structural and functional brain imaging findings in antisocial, violent, and psychopathic individuals: a meta-analysis. Psychiatry Res 174:81-8
Miczek, Klaus A; de Almeida, Rosa M M; Kravitz, Edward A et al. (2007) Neurobiology of escalated aggression and violence. J Neurosci 27:11803-6