Early environments that developing organisms encounter during ontogeny have profound and persistent effects throughout life. In human offspring, variation in early family environments and gestational endocrine environments can profoundly shape multiple biosocial parameters, including sociality and behavior, stress reactivity, pubertal timing, and later parental style. We will examine the impact of early environments on development in a marmoset model that is relevant to human development. Marmoset development occurs in a family system, with multiple caregivers providing qualitatively and quantitatively different forms of care. Further, mothers often conceive immediately postpartum, leading to elevated maternal steroid hormones (including androgens) that can impact both developing fetuses (via placental transfer) and nursing offspring (via milk-borne steroids), a condition often found in human females (e.g., polycystic ovarian syndrome). In addition, female marmosets also exhibit elevated and varying levels of glucocorticoid hormones during pregnancy, suggesting that offspring may be differentially affected. The studies described in this application will address 3 aims: 1) Does variation in early care produce phenotypic variation in behavioral, physiological, and parental care?;2) How is behavioral, somatic, and reproductive development shaped by pre- and postnatal exogenous steroids in marmosets?;and 3) does variation in gestational exposure to glucocorticoid hormone alter developmental trajectories, particularly in the stress system and somatic development? Using an established colony of marmosets, we will evaluate the links between early care received by marmosets and later parental care toward their own offspring. Secondly, we will look for associations among maternal androgens during gestation and during lactation (including concentrations in milk) and subsequent biobehavioral parameters. Finally, we will monitor cortisol responses to a standardized psychosocial stressor to evaluate whether exposure to high fetal glucocorticoids programs marmosets to be stress-responsive.

Public Health Relevance

Differences in early uterine and postnatal social environments predispose developing offspring toward characteristics that have health relevance (e.g., pubertal timing, stress reactivity, sociality). These projects will assess the impact of early environments on biosocial development in marmosets, a species with many similarities to human sociality and biology.

National Institute of Health (NIH)
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Research Project (R01)
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Study Section
Biobehavioral Regulation, Learning and Ethology Study Section (BRLE)
Program Officer
Esposito, Layla E
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University of Nebraska Omaha
Schools of Arts and Sciences
United States
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Mustoe, Aaryn; Taylor, Jack H; French, Jeffrey A (2018) Oxytocin structure and function in New World monkeys: from pharmacology to behavior. Integr Zool 13:634-654
French, Jeffrey A; Cavanaugh, Jon; Mustoe, Aaryn C et al. (2018) Social Monogamy in Nonhuman Primates: Phylogeny, Phenotype, and Physiology. J Sex Res 55:410-434
Cavanaugh, Jon; Mustoe, Aaryn; French, Jeffrey A (2018) Oxytocin regulates reunion affiliation with a pairmate following social separation in marmosets. Am J Primatol 80:e22750
Cavanaugh, Jon; Mustoe, Aaryn; Womack, Stephanie L et al. (2018) Oxytocin modulates mate-guarding behavior in marmoset monkeys. Horm Behav 106:150-161
Mustoe, Aaryn C; Harnisch, April M; Hochfelder, Benjamin et al. (2016) Inequity aversion strategies between marmosets are influenced by partner familiarity and sex but not oxytocin. Anim Behav 114:69-79
French, Jeffrey A; Carp, Sarah B (2016) Early-life Social Adversity and Developmental Processes in Nonhuman Primates. Curr Opin Behav Sci 7:40-46
French, Jeffrey A (2016) Genes, dopamine pathways, and sociality in primates. Proc Natl Acad Sci U S A 113:6325-7
Cavanaugh, Jon; Carp, Sarah B; Rock, Chelsea M et al. (2016) Oxytocin modulates behavioral and physiological responses to a stressor in marmoset monkeys. Psychoneuroendocrinology 66:22-30
French, Jeffrey A; Taylor, Jack H; Mustoe, Aaryn C et al. (2016) Neuropeptide diversity and the regulation of social behavior in New World primates. Front Neuroendocrinol 42:18-39
Taylor, Jack H; French, Jeffrey A (2015) Oxytocin and vasopressin enhance responsiveness to infant stimuli in adult marmosets. Horm Behav 75:154-9

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