Spasticity, contracture, and muscle weakness are major sources of disability following brain damage, and their development and recovery are closely interrelated. Increased resistance to passive movement in spastic hypertonia can be due to reflex (with both tonic and phasic components) and/or non-reflex (with both viscous damping and elastic stiffness components) changes. The various components contributing to spastic hypertonia and functional deficits following stroke, and the outcome of an intelligent stretching treatment in changing these components and functional performance will be investigated over 7 months for each patient. The first specific aim is to treat/stretch spastic ankle joints in stroke patients safely and repeatedly to joint extreme positions until a pre-specified peak resistance torque is reached with the stretching velocity adjusted constantly and inversely proportional to the resistance torque. The second specific aim is to evaluate pathophysiological changes in spastic hypertonia and to assess outcome of the stretching treatment in terms of both reflex (dynamic and static stretch-reflex gains corresponding to phasic and tonic reflex actions, respectively) and non-reflex (joint elastic stiffness and viscous damping characterizing displacement- and velocity- dependent resistances, respectively) changes in spastic ankles of stroke patients through in vivo experiments under both passive (muscle relaxed) and active muscle contracting) conditions over a period of 4 months. The third specific aim is to investigate stretching-induced changes in functional performance and the underlying mechanisms in terms of muscle force-generating capacity, maximum voluntary contraction (MVC), mechanical properties of the Achilles tendon and aponeurosis investigated using ultrasonography, torque-angle relationship of the triceps surae muscles, plantar and dorsi flexor co-contraction, and active ROM before and after stretching and over the period of 4 months. The long-term goals are to provide effective, convenient, and low-cost treatments of spastic limbs in neurologically impaired patients with quantitative outcome evaluation in multiple aspects.

Agency
National Institute of Health (NIH)
Institute
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Type
Research Project (R01)
Project #
5R01HD044295-03
Application #
6881074
Study Section
Geriatrics and Rehabilitation Medicine (GRM)
Program Officer
Ansel, Beth
Project Start
2003-02-01
Project End
2007-01-31
Budget Start
2005-02-01
Budget End
2006-01-31
Support Year
3
Fiscal Year
2005
Total Cost
$225,945
Indirect Cost
Name
Rehabilitation Institute of Chicago
Department
Type
DUNS #
068477546
City
Chicago
State
IL
Country
United States
Zip Code
60611
Wu, Yi-Ning; Park, Hyung-Soon; Chen, Jia-Jin et al. (2018) Position as Well as Velocity Dependence of Spasticity-Four-Dimensional Characterizations of Catch Angle. Front Neurol 9:863
Zhao, Heng; Ren, Yupeng; Roth, Elliot J et al. (2015) Concurrent deficits of soleus and gastrocnemius muscle fascicles and Achilles tendon post stroke. J Appl Physiol (1985) 118:863-71
Peng, Qiyu; Park, Hyung-Soon; Shah, Parag et al. (2011) Quantitative evaluations of ankle spasticity and stiffness in neurological disorders using manual spasticity evaluator. J Rehabil Res Dev 48:473-81
Liu, Jie; Xu, Dali; Ren, Yupeng et al. (2011) Evaluations of neuromuscular dynamics of hyperactive reflexes poststroke. J Rehabil Res Dev 48:577-86
Gao, Fan; Ren, Yupeng; Roth, Elliot J et al. (2011) Effects of repeated ankle stretching on calf muscle-tendon and ankle biomechanical properties in stroke survivors. Clin Biomech (Bristol, Avon) 26:516-22
Park, Hyung-Soon; Ahn, Chulhyun; Fung, David T et al. (2010) A knee-specific finite element analysis of the human anterior cruciate ligament impingement against the femoral intercondylar notch. J Biomech 43:2039-42
Wu, Yi-Ning; Ren, Yupeng; Zhang, Li-Qun (2010) In vivo sarcomere imaging and fiber tension measurements. Conf Proc IEEE Eng Med Biol Soc 2010:1986-9
Wu, Yi-Ning; Ren, Yupeng; Hwang, Miriam et al. (2010) Efficacy of robotic rehabilitation of ankle impairments in children with cerebral palsy. Conf Proc IEEE Eng Med Biol Soc 2010:4481-4
Gao, Fan; Grant, Thomas H; Roth, Elliot J et al. (2009) Changes in passive mechanical properties of the gastrocnemius muscle at the muscle fascicle and joint levels in stroke survivors. Arch Phys Med Rehabil 90:819-26
Chung, Sun G; van Rey, Elton; Bai, Zhiqiang et al. (2008) Separate quantification of reflex and nonreflex components of spastic hypertonia in chronic hemiparesis. Arch Phys Med Rehabil 89:700-10

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