Agency
National Institute of Health (NIH)
Institute
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Type
Research Project (R01)
Project #
5R01HD046943-04
Application #
7090718
Study Section
Pediatrics Subcommittee (CHHD)
Program Officer
Urv, Tiina K
Project Start
2003-09-01
Project End
2008-07-31
Budget Start
2006-08-01
Budget End
2007-07-31
Support Year
4
Fiscal Year
2006
Total Cost
$284,850
Indirect Cost
Name
Massachusetts Institute of Technology
Department
Miscellaneous
Type
Schools of Arts and Sciences
DUNS #
001425594
City
Cambridge
State
MA
Country
United States
Zip Code
02139
Stoppel, Laura J; Auerbach, Benjamin D; Senter, Rebecca K et al. (2017) ?-Arrestin2 Couples Metabotropic Glutamate Receptor 5 to Neuronal Protein Synthesis and Is a Potential Target to Treat Fragile X. Cell Rep 18:2807-2814
Sidorov, Michael S; Kaplan, Eitan S; Osterweil, Emily K et al. (2015) Metabotropic glutamate receptor signaling is required for NMDA receptor-dependent ocular dominance plasticity and LTD in visual cortex. Proc Natl Acad Sci U S A 112:12852-7
Tian, Di; Stoppel, Laura J; Heynen, Arnold J et al. (2015) Contribution of mGluR5 to pathophysiology in a mouse model of human chromosome 16p11.2 microdeletion. Nat Neurosci 18:182-4
Sidorov, M S; Krueger, D D; Taylor, M et al. (2014) Extinction of an instrumental response: a cognitive behavioral assay in Fmr1 knockout mice. Genes Brain Behav 13:451-8
Chubykin, Alexander A; Roach, Emma B; Bear, Mark F et al. (2013) A cholinergic mechanism for reward timing within primary visual cortex. Neuron 77:723-35
Osterweil, Emily K; Chuang, Shih-Chieh; Chubykin, Alexander A et al. (2013) Lovastatin corrects excess protein synthesis and prevents epileptogenesis in a mouse model of fragile X syndrome. Neuron 77:243-50
Krueger, Dilja D; Bear, Mark F (2011) Toward fulfilling the promise of molecular medicine in fragile X syndrome. Annu Rev Med 62:411-29
Javitt, Daniel C; Schoepp, Darryle; Kalivas, Peter W et al. (2011) Translating glutamate: from pathophysiology to treatment. Sci Transl Med 3:102mr2
Auerbach, Benjamin D; Osterweil, Emily K; Bear, Mark F (2011) Mutations causing syndromic autism define an axis of synaptic pathophysiology. Nature 480:63-8
Krueger, Dilja D; Osterweil, Emily K; Chen, Stephanie P et al. (2011) Cognitive dysfunction and prefrontal synaptic abnormalities in a mouse model of fragile X syndrome. Proc Natl Acad Sci U S A 108:2587-92

Showing the most recent 10 out of 14 publications