Physical rehabilitation is the main treatment for motor disorders. Yet we are far from understanding the essential principles of rehabilitation training in adults, and know even less about children. Our long-term goals are to identify critical features of the motor learning process, understand how they change during development, and discover how to optimize them for rehabilitating children and adults with hemiparesis. Here we focus on optimizing motor learning during split-belt treadmill training, a technique that shows strong promise for producing dramatic improvements in walking patterns. We have shown that deficit exaggeration during split-belt training can correct walking deficits in children and adults with hemiparesis. Specifically, exaggerating the problem by making one leg walk faster than the other drives the nervous system to adapt, and this improves walking patterns when the person returns to normal conditions. We believe that split-belt deficit exaggeration could become an important clinical approach. However, there are two critical motor learning features requiring further study to guide clinical application. First, we need to optimize generalization from split-belt walking to walking under natural conditions. Split-belt adaptation generalizes only partially to natural over-ground walking. This is a common problem with any device or robot based training strategy, where training conditions do not match real-world contexts. Thus, we will study how manipulating the sensory context with virtual reality and changing attention to the movement influence generalization. Second, we need to optimize retention of adapted walking patterns, in order to produce long-term improvements in natural walking. In previous experiments, adaptation faded within 10 20 minutes. In the proposed experiments, we will study how attention and training schedule can be used to extend retention. In all three aims, we will assess effects of age (3-adult) and presence of hemiparesis from cerebral damage. Overall, we believe our results will show how deficit exaggeration during split-belt treadmill training could be used to produce long-term improvements in natural walking.

Public Health Relevance

Walking disturbances are some of the most common problems for people with brain damage. In this grant, we will work to understand how split-belt treadmill training can help people learn to improve their walking patterns.

Agency
National Institute of Health (NIH)
Institute
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Type
Research Project (R01)
Project #
2R01HD048741-05A1
Application #
7986164
Study Section
Musculoskeletal Rehabilitation Sciences Study Section (MRS)
Program Officer
Ansel, Beth
Project Start
2006-07-01
Project End
2015-05-31
Budget Start
2010-08-01
Budget End
2011-05-31
Support Year
5
Fiscal Year
2010
Total Cost
$315,886
Indirect Cost
Name
Hugo W. Moser Research Institute Kennedy Krieger
Department
Type
DUNS #
155342439
City
Baltimore
State
MD
Country
United States
Zip Code
21205
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