This R01 application is one of four coordinated R01 Grants whose primary focus is the prospective characterization of effects on variation in the early social, emotional and behavioral problems of young children of gene-environment interplay (GE correlation and GxE interaction). This R01 makes use of a children-of-twins (COT) paradigm, building upon a prospective study of female like-sex twin pairs who were first assessed in adolescence (N=3277 twins assessed at wave 4 in early adulthood, ages 18-26). The COT design is particularly powerful for resolving (i) GE correlation effects associated with partner selection, (ii) GE correlation effects arising because heritable traits in parents predict increased probability of offspring high risk environmental exposures. Hypothesis-testing will be integrated within a theoretical framework that considers 3 meta-models -(behavioral under-control/disinhibition; behavioral inhibition/negative affect; pharmacologic impairment/substance dependence) for understanding how genetic and phenotypic differences between young women, in combination with differences in early experience (childhood trauma, rearing environment), contribute to risk of a progressive cascade of environmental risk for their present or future offspring. Gene-environment interplay is considered from a developmental perspective that considers pre-conception effects (partner selection, relationship formation), prenatal effects (early versus delayed pregnancy, maternal smoking and drinking during pregnancy), immediate post-natal environment (family socioeconomic disadvantage, high-risk neighborhood), early family environment (parent-parent relationship and relationship dissolution, and parenting behaviors; early traumatic events) and external environmental influences (access to high quality day-care, schooling). Two waves of data collection from the young adult female twin pairs, by telephone interview (target N=2622 interviews at wave one, N=2490 interviews at 2-year follow-up) will characterize relationship and pregnancy histories and early parenting behavior, perceived partner behavioral and emotional problems (projected N=2100 partners, with 20 percent completing interviews at each wave) and children's emotional and behavioral problems (projected N=2000 offspring), and will obtain updated assessments of twin risk-factors. In conjunction with R01s 2-4, these data will permit a powerful resolution of hypotheses concerning GE interplay effects on young children.

Agency
National Institute of Health (NIH)
Institute
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Type
Research Project (R01)
Project #
5R01HD049024-04
Application #
7344869
Study Section
Special Emphasis Panel (ZRG1-HOP-C (02))
Program Officer
Freund, Lisa S
Project Start
2005-01-01
Project End
2009-12-31
Budget Start
2008-01-01
Budget End
2008-12-31
Support Year
4
Fiscal Year
2008
Total Cost
$603,557
Indirect Cost
Name
Washington University
Department
Psychiatry
Type
Schools of Medicine
DUNS #
068552207
City
Saint Louis
State
MO
Country
United States
Zip Code
63130
Micalizzi, Lauren; Marceau, Kristine; Brick, Leslie A et al. (2018) Inhibitory control in siblings discordant for exposure to maternal smoking during pregnancy. Dev Psychol 54:199-208
Sartor, Carolyn E; Grant, Julia D; Few, Lauren R et al. (2018) Childhood Trauma and Two Stages of Alcohol Use in African American and European American Women: Findings from a Female Twin Sample. Prev Sci 19:795-804
Waldron, Mary; Watkins, Nicole K; Bucholz, Kathleen K et al. (2018) Interactive Effects of Maternal Alcohol Problems and Parental Separation on Timing of Daughter's First Drink. Alcohol Clin Exp Res 42:120-127
Marceau, Kristine; Cinnamon Bidwell, L; Karoly, Hollis C et al. (2018) Within-Family Effects of Smoking during Pregnancy on ADHD: the Importance of Phenotype. J Abnorm Child Psychol 46:685-699
Bidwell, L Cinnamon; Marceau, Kristine; Brick, Leslie A et al. (2017) Prenatal Exposure Effects on Early Adolescent Substance Use: Preliminary Evidence From a Genetically Informed Bayesian Approach. J Stud Alcohol Drugs 78:789-794
Waldron, Mary; Bucholz, Kathleen K; Lian, Min et al. (2017) Single Motherhood, Alcohol Dependence, and Smoking During Pregnancy: A Propensity Score Analysis. J Stud Alcohol Drugs 78:745-753
Agrawal, Arpana; Grant, Julia D; Haber, Jon Randolph et al. (2017) Differences between White and Black young women in the relationship between religious service attendance and alcohol involvement. Am J Addict 26:437-445
Grant, Julia D; Agrawal, Arpana; Werner, Kimberly B et al. (2017) Phenotypic and familial associations between childhood maltreatment and cannabis initiation and problems in young adult European-American and African-American women. Drug Alcohol Depend 179:146-152
Agrawal, Arpana; Grant, Julia D; Lynskey, Michael T et al. (2016) The genetic relationship between cannabis and tobacco cigarette use in European- and African-American female twins and siblings. Drug Alcohol Depend 163:165-71
Knopik, Valerie S; Marceau, Kristine; Palmer, Rohan H C et al. (2016) Maternal Smoking During Pregnancy and Offspring Birth Weight: A Genetically-Informed Approach Comparing Multiple Raters. Behav Genet 46:353-64

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