At least 60% of children treated for medulloblastoma with contemporary multimodality therapy (i.e., surgica resection, radiation therapy, and high-dose chemotherapy) will live more than 5 years after initial diagnosis Unfortunately, the majority of these survivors ultimately experience IQ loss, learning difficulties, an academic failure. The long-term goal of our research is to identify neural substrates of cognitive deficit among long-term survivors of childhood cancer. The focus of this application is deficits in reading ability The study is designed to test the hypothesis that behavioral deficits in reading decoding amon medulloblastoma survivors reflect therapy-induced disruption of ventral visual processing during th development of reading skills. Functional magnetic resonance imaging (fMRI) and diffusion tensor imagin (DTI) will be used in a longitudinal study to compare neural systems for orthographic processing in patient and age-similar controls. The neuroimaging data (fMRI and DTI) will be analyzed in relation to behaviora performance on a comprehensive battery of neuropsychological tests This research will generate important insights into the fundamental causes of cognitive deficits associate with medulloblastoma therapy, identify potential targets for pharmacological and behavioral interventions t improve cognitive function in survivors who have already been treated, and discover opportunities to reduc the negative impact of medulloblastoma therapy on patients treated in the future. Furthermore, th medulloblastoma survivors will serve as a model population with acquired dyslexia related to well-define therapeutic insult. The longitudinal behavioral and imaging studies in patients and healthy controls may yiel new insights into the role of the ventral visual system in development of normal and abnormal reading abilit in otherwise healthy children.

National Institute of Health (NIH)
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Research Project (R01)
Project #
Application #
Study Section
Language and Communication Study Section (LCOM)
Program Officer
Miller, Brett
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
St. Jude Children's Research Hospital
United States
Zip Code
Kawauchi, D; Ogg, R J; Liu, L et al. (2017) Novel MYC-driven medulloblastoma models from multiple embryonic cerebellar cells. Oncogene 36:5231-5242
Glass, John O; Ogg, Robert J; Hyun, Jung W et al. (2017) Disrupted development and integrity of frontal white matter in patients treated for pediatric medulloblastoma. Neuro Oncol 19:1408-1418
Zou, Ping; Conklin, Heather M; Scoggins, Matthew A et al. (2016) Functional MRI in medulloblastoma survivors supports prophylactic reading intervention during tumor treatment. Brain Imaging Behav 10:258-71
King, Benjamin A; Parra, Carlos; Li, Yimei et al. (2015) Spatiotemporal Patterns of Tumor Occurrence in Children with Intraocular Retinoblastoma. PLoS One 10:e0132932
Hsieh, Hui-Min; Gu, Song-Mao; Shin, Shyi-Jang et al. (2015) Cost-Effectiveness of a Diabetes Pay-For-Performance Program in Diabetes Patients with Multiple Chronic Conditions. PLoS One 10:e0133163
Edelmann, Michelle N; Krull, Kevin R; Liu, Wei et al. (2014) Diffusion tensor imaging and neurocognition in survivors of childhood acute lymphoblastic leukaemia. Brain 137:2973-83
Winchell, A M; Taylor, B A; Song, R et al. (2014) Evaluation of SWI in children with sickle cell disease. AJNR Am J Neuroradiol 35:1016-21
Uh, Jinsoo; Merchant, Thomas E; Li, Yimei et al. (2013) Differences in brainstem fiber tract response to radiation: a longitudinal diffusion tensor imaging study. Int J Radiat Oncol Biol Phys 86:292-7
Hua, Chiaho; Merchant, Thomas E; Gajjar, Amar et al. (2012) Brain tumor therapy-induced changes in normal-appearing brainstem measured with longitudinal diffusion tensor imaging. Int J Radiat Oncol Biol Phys 82:2047-54
Palmer, Shawna L; Glass, John O; Li, Yimei et al. (2012) White matter integrity is associated with cognitive processing in patients treated for a posterior fossa brain tumor. Neuro Oncol 14:1185-93

Showing the most recent 10 out of 20 publications