Although the link between maternal and child depression is well established, little is known about the mechanisms by which this risk is conferred. The proposed study is designed to address this gap. In so doing, we seek to integrate and extend findings from two separate lines of research: cognitive-interpersonal models of depression and psychiatric genetics. The proposed study involves a longitudinal investigation of mothers and their children (ages 8-14 years) drawn from the community and assessed every six months for two years. Two groups of mothers will be recruited for the study: (a) those with a history of major depressive disorder (MDD) during their child's life and (b) those with no lifetime history of any depressive disorder and no current Axis I disorder. Our primary goal is to examine the development of children's cognitive vulnerability to depression (negative attributional style and attention and interpretation biases for facial displays of emotion). We hypothesize that maternal history of MDD will be associated with the presence of more negative cognitive styles in their children and that these cognitive styles will become more negative over the course of the follow-up as a function of mother's ongoing depressive symptom levels. We also hypothesize that negative events in the children's lives (maternal criticism as well as general negative events) will predict negative changes in children's cognitive styles. Integrating recent findings from psychiatric genetics, we predict that these effects on children's cognitive styles will be moderated by two specific genetic risk factors - a functional polymorphism in the serotonin transporter gene (5-HTTLPR) and a candidate polymorphism in the brain-derived neurotrophic factor (BDNF) gene. Our secondary goal is to test a transactional cognitive-interpersonal mediation model linking maternal and child depression. In testing this model, we hypothesize that mothers with a history of MDD, compared to control mothers, will exhibit elevated levels of depressive symptoms across the follow-up. These depressive symptom elevations are hypothesized to contribute to the occurrence of negative events in children's lives, which will then contribute to the development of children's negative cognitive styles. These negative cognitive styles, then, are hypothesized to contribute to children's symptoms and diagnoses of depression. Building from the stress-generation literature, we will also test the hypothesis that children's levels of depression will reciprocally predict prospective changes in negative events and children's cognitive styles. We also predict that children's 5-HTTLPR and BDNF genotypes will moderate the impact of mother depression, negative events, and children's cognitions upon child depression, allowing increased precision in predicting which children are at greatest risk for the intergenerational transmission of depression. A tertiary goal is to examine the specificity of the links in the mediational model to children's depression versus other disorders (e.g., anxiety and disruptive behavior disorders).

Public Health Relevance

The proposed study represents an important step in understanding why children of depressed mothers are at increased risk for depression themselves. If the proposed developmental model is supported, the results could help to further advance efforts for the early detection of children at greatest risk of developing depression. In addition, the results could pave the way for more focused interventions for at-risk children.

Agency
National Institute of Health (NIH)
Institute
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Type
Research Project (R01)
Project #
5R01HD057066-02
Application #
7945335
Study Section
Child Psychopathology and Developmental Disabilities Study Section (CPDD)
Program Officer
Esposito, Layla E
Project Start
2009-09-30
Project End
2011-08-31
Budget Start
2010-09-01
Budget End
2011-08-31
Support Year
2
Fiscal Year
2010
Total Cost
$487,166
Indirect Cost
Name
State University of NY, Binghamton
Department
Psychology
Type
Schools of Arts and Sciences
DUNS #
090189965
City
Binghamton
State
NY
Country
United States
Zip Code
13902
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Tsypes, Aliona; Owens, Max; Hajcak, Greg et al. (2018) Neural reward responsiveness in children who engage in nonsuicidal self-injury: an ERP study. J Child Psychol Psychiatry 59:1289-1297
Meyer, Alexandria; Bress, Jennifer N; Hajcak, Greg et al. (2018) Maternal Depression Is Related to Reduced Error-Related Brain Activity in Child and Adolescent Offspring. J Clin Child Adolesc Psychol 47:324-335
Woody, Mary L; Burkhouse, Katie L; Siegle, Greg J et al. (2017) Pupillary response to emotional stimuli as a risk factor for depressive symptoms following a natural disaster: The 2011 Binghamton flood. Clin Psychol Sci 5:726-732
Feurer, Cope; Burkhouse, Katie L; Siegle, Greg et al. (2017) Increased pupil dilation to angry faces predicts interpersonal stress generation in offspring of depressed mothers. J Child Psychol Psychiatry 58:950-957
Feurer, Cope; McGeary, John E; Knopik, Valerie S et al. (2017) HPA axis multilocus genetic profile score moderates the impact of interpersonal stress on prospective increases in depressive symptoms for offspring of depressed mothers. J Abnorm Psychol 126:1017-1028
Tsypes, Aliona; Burkhouse, Katie L; Gibb, Brandon E (2016) Classification of facial expressions of emotion and risk for suicidal ideation in children of depressed mothers: Evidence from cross-sectional and prospective analyses. J Affect Disord 197:147-50
Kudinova, Anastacia Y; Deak, Terrence; Hueston, Cara M et al. (2016) Cross-species evidence for the role of interleukin-33 in depression risk. J Abnorm Psychol 125:482-94
Kudinova, Anastacia Y; Burkhouse, Katie L; Siegle, Greg et al. (2016) Pupillary reactivity to negative stimuli prospectively predicts recurrence of major depressive disorder in women. Psychophysiology 53:1836-1842

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