The capacity to represent the world in terms of numerically distinct objects is a milestone in early cognitive development and forms the foundation for more complex thought and behavior. Failure to develop this capacity places infants at significant risk for later developmental difficulties. Recent research has revealed important developmental changes in infants'ability to use featural information to individuate objects. However, relatively little is known about the neural mechanisms that underlie these changes, in large part because there are a limited number of non-invasive techniques available to measure brain function in infants. Hence, there is a critical need to identify new methods to specify the relation between behavior and brain function in object processing. One such method is near-infrared spectroscopy (NIRS), an optical imaging technique that uses changes in cerebral blood volume as an indicator of neural activation. Because NIRS is safe and non-invasive, can be used during behavioral tasks, and provides spatial and temporal information about neural activation, it is ideal for infant research of this kind. The research proposed in this application will use NIRS to identity changes in neural activation during object processing tasks. The objective of this application is to identify the neural basis of infants'ability to (a) use shape, size, color, and luminance information to individuate objects and (b) extract shape from a variety of perceptual cues (e.g., coherent motion and contour). The central hypothesis is that infants'capacity to individuate objects using shape, color, and luminance differences will be associated with unique, well-defined patterns of neural activation in higher level object processing areas. In addition, infants'capacity to perceive the shape of an object on the basis of coherent motion and connected contour will be associated with unique patterns of neural activation in extrastriate cortex. This hypothesis has been formulated on the basis of behavioral and neuroimaging data collected in our lab. The rationale for the proposed research is that once we have identified the neural substrates that support featurally-based object representation and individuation in the infant, it will be possible to formulate a developmental model of object processing that focuses on brain-behavior relations.

Public Health Relevance

The information that will be gained by the proposed research can be used to help guide the development of diagnostic and intervention techniques that can be used with infants at risk for object processing difficulties. Early detection of object processing difficulties, and appropriate intervention, can be expected to significantly reduce the extent to which later emerging cognitive dysfunction is observed in at risk infants. The information gained by the proposed studies will also provide the impetus for new research that examines the extent to which normal patterns of behavior and brain function are affected by specific medical conditions and differences in early experience.

National Institute of Health (NIH)
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Research Project (R01)
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Central Visual Processing Study Section (CVP)
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Freund, Lisa S
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Texas A&M University
Schools of Arts and Sciences
College Station
United States
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Hirshkowitz, Amy; Biondi, Marisa; Wilcox, Teresa (2018) Cortical responses to shape-from-motion stimuli in the infant. Neurophotonics 5:011014
Alexander, Gerianne M; Hawkins, Laura B; Wilcox, Teresa et al. (2016) Infants Prefer Female Body Phenotypes; Infant Girls Prefer They Have an Hourglass Shape. Front Psychol 7:804
Biondi, Marisa; Boas, David A; Wilcox, Teresa (2016) On the other hand: Increased cortical activation to human versus mechanical hands in infants. Neuroimage 141:143-153
Wilcox, Teresa; Biondi, Marisa (2015) fNIRS in the developmental sciences. Wiley Interdiscip Rev Cogn Sci 6:263-83
Wilcox, Teresa; Biondi, Marisa (2015) Functional Activation in the Ventral Object Processing Pathway during the First Year. Front Syst Neurosci 9:180
Wilcox, Teresa; Biondi, Marisa (2015) Object processing in the infant: lessons from neuroscience. Trends Cogn Sci 19:406-13
Wilcox, Teresa; Hawkins, Laura B; Hirshkowitz, Amy et al. (2014) Cortical activation to object shape and speed of motion during the first year. Neuroimage 99:129-41
Wilcox, Teresa; Hirshkowitz, Amy; Hawkins, Laura et al. (2014) The effect of color priming on infant brain and behavior. Neuroimage 85 Pt 1:302-13
Hirshkowitz, Amy; Wilcox, Teresa (2013) Infants' ability to extract three-dimensional shape from coherent motion. Infant Behav Dev 36:863-72
Wilcox, Teresa; Stubbs, Jessica A; Wheeler, Lesley et al. (2013) Infants' scanning of dynamic faces during the first year. Infant Behav Dev 36:513-6

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