The early school age period is a time of significant developmental change in both cognitive abilities and neural systems. Yet little is known about how, specifically, these developmental processes that occur concurrently are linked to each other, or about the nature of critical interactions of biological factors with childhood experiences and environments. The proposed project takes a critical first step in addressing this problem by examining, in unprecedented detail, the development of basic cognitive processes and of the neural systems that mediate them during the child's transition to formal schooling. The design is a longitudinal study of 100 typically- developing children inducted at age 6 and assessed with behavioral measures and MRI annually on 5 occasions. The behavioral measures to be collected, of language, visuospatial processing, working memory, and cognitive control, have exhibited high sensitivity to developmental change over this age range. MR imaging of the children will involve recently developed, improved methods for image acquisition and computational modeling of the results. Diffusion parameters from specific brain fiber tracts as well as regional measures of cortical surface area and thickness will be measured. The focus of the study is on differences in the rate of fiber tract development from 6 to 10 years of age and links between this variability and the pace of cognitive development. Relationships between the neural parameters and early academic achievement will also be examined. The study is novel, not only because the imaging methods to be applied will produce more detailed information about the brains of children than is currently available, but also because of the conceptual focus of the project on the degree of concordance between trajectories of brain and behavioral development. The long-term significance of the study lies in its potential to guide us toward interventions that are more adaptive to individual differences and therefore promote positive outcomes in more children.

Public Health Relevance

The research described in this application will use magnetic resonance imaging to determine how much healthy children differ from each other in the rate at which their brains develop biologically, particularly in the connecting fibers that transmit information within the brain, and how closely this mirrors the pace of their mental development.
The aim of the research is to increase our understanding of differences among children so that we can use this knowledge to create more supportive environments for all children, and also to guide us toward interventions that may allow us to prevent some mental illnesses.

National Institute of Health (NIH)
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Research Project (R01)
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Study Section
Child Psychopathology and Developmental Disabilities Study Section (CPDD)
Program Officer
Freund, Lisa S
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University of California San Diego
Schools of Arts and Sciences
La Jolla
United States
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Wierenga, Lara M; van den Heuvel, Martijn P; Oranje, Bob et al. (2018) A multisample study of longitudinal changes in brain network architecture in 4-13-year-old children. Hum Brain Mapp 39:157-170
Curley, Lauren B; Newman, Erik; Thompson, Wesley K et al. (2018) Cortical morphology of the pars opercularis and its relationship to motor-inhibitory performance in a longitudinal, developing cohort. Brain Struct Funct 223:211-220
Akshoomoff, Natacha; Brown, Timothy T; Bakeman, Roger et al. (2018) Developmental differentiation of executive functions on the NIH Toolbox Cognition Battery. Neuropsychology 32:777-783
Li, Yi; Barkovich, Matthew J; Karch, Celeste M et al. (2018) Regionally specific TSC1 and TSC2 gene expression in tuberous sclerosis complex. Sci Rep 8:13373
Barkovich, Matthew J; Tan, Chin Hong; Nillo, Ryan M et al. (2018) Abnormal Morphology of Select Cortical and Subcortical Regions in Neurofibromatosis Type 1. Radiology 289:499-508
Jernigan, Terry L; Stiles, Joan (2017) Construction of the human forebrain. Wiley Interdiscip Rev Cogn Sci 8:
Glass, Leila; Moore, Eileen M; Akshoomoff, Natacha et al. (2017) Academic Difficulties in Children with Prenatal Alcohol Exposure: Presence, Profile, and Neural Correlates. Alcohol Clin Exp Res 41:1024-1034
Braddick, Oliver; Atkinson, Janette; Akshoomoff, Natacha et al. (2017) Individual differences in children's global motion sensitivity correlate with TBSS-based measures of the superior longitudinal fasciculus. Vision Res 141:145-156
Akshoomoff, Natacha; Joseph, Robert M; Taylor, H Gerry et al. (2017) Academic Achievement Deficits and Their Neuropsychological Correlates in Children Born Extremely Preterm. J Dev Behav Pediatr 38:627-637
Jernigan, Terry L; Brown, Timothy T; Hagler Jr, Donald J et al. (2016) The Pediatric Imaging, Neurocognition, and Genetics (PING) Data Repository. Neuroimage 124:1149-54

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