Cerebral palsy (CP) is the most common pediatric neurological disorder. CP is caused by damage to brain motor areas during development. CP results in weakness, altered tone and abnormal coordination. Therapies for CP have largely been scaled from adult stroke therapies. However, the motor circuits involved in adult stroke are quite different from those in children with CP. Effective therapies for children with CP should be built on a specific understanding of motor circuit control in children with CP. We propose to identify the neurophysiological underpinnings of hand control in children with CP and will determine predictors of the efficacy of hand therapy. Building an understanding of hand motor control in children with CP fills an important gap and will set the foundation for further development of hand therapies for children with CP. Two types of intensive hand training have shown efficacy in children with unilateral spastic CP (USCP), whose motor deficits are largely restricted to one side of the body. In constraint-induced movement therapy (CIMT), the dominant arm is restrained while the impaired hand is trained in unimanual tasks. In hand-arm intensive bimanual training (HABIT), alternatively, children use both hands together. It has been reported that the efficacy of CIMT is affected by the pattern of corticospinal tract connectivity i children with USCP. The central hypothesis of the proposed research, supported by our pilot data, is that efficacy of hand training is differentially affected by connectivity of motor circuit and type of training. We also hypothesize that neurophysiological biomarkers of motor circuit dysfunction can predict which type of hand training is ideal for an individual. Two important questions remain unanswered: 1) How do motor circuits interact and change in response to intensive hand therapy? 2) Does the efficacy of intensive hand therapy depend on laterality of the corticospinal tract that controls the affected hand? The proposed experiments will answer these questions. Children are not little adults. Therapies for USCP must be built on a strong understanding of motor control in USCP. By identifying the neural circuit effects of CIMT vs. HABIT, we can tailor therapies to children most likely to benefit. This work will also provide a framework for developing new activity-based therapies for USCP.

Public Health Relevance

Unilateral cerebral palsy is an extremely common pediatric neurological disorder. The goal of the proposed studies is to test the novel hypothesis that the efficacy of different types of hand therapy depends on the connectivity and integrity of motor pathways in the brain. Understanding the impact of brain connectivity on recovery will provide important insights into how to develop and tailor therapies for children most likely to benefit.

National Institute of Health (NIH)
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Research Project (R01)
Project #
Application #
Study Section
Musculoskeletal Rehabilitation Sciences Study Section (MRS)
Program Officer
Nitkin, Ralph M
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
Winifred Masterson Burke Med Research Institute
White Plains
United States
Zip Code
Gillick, Bernadette T; Gordon, Andrew M; Feyma, Tim et al. (2018) Non-Invasive Brain Stimulation in Children With Unilateral Cerebral Palsy: A Protocol and Risk Mitigation Guide. Front Pediatr 6:56
Marneweck, Michelle; Kuo, Hsing-Ching; Smorenburg, Ana R P et al. (2018) The Relationship Between Hand Function and Overlapping Motor Representations of the Hands in the Contralesional Hemisphere in Unilateral Spastic Cerebral Palsy. Neurorehabil Neural Repair 32:62-72
Smorenburg, Ana R P; Gordon, Andrew M; Kuo, Hsing-Ching et al. (2017) Does Corticospinal Tract Connectivity Influence the Response to Intensive Bimanual Therapy in Children With Unilateral Cerebral Palsy? Neurorehabil Neural Repair 31:250-260
Saussez, Geoffroy; Brandão, Marina B; Gordon, Andrew M et al. (2017) Including a Lower-Extremity Component during Hand-Arm Bimanual Intensive Training does not Attenuate Improvements of the Upper Extremities: A Retrospective Study of Randomized Trials. Front Neurol 8:495
Kuo, Hsing-Ching; Ferre, Claudio L; Carmel, Jason B et al. (2017) Using diffusion tensor imaging to identify corticospinal tract projection patterns in children with unilateral spastic cerebral palsy. Dev Med Child Neurol 59:65-71
Gupta, Disha; Barachant, Alexandre; Gordon, Andrew M et al. (2017) Effect of sensory and motor connectivity on hand function in pediatric hemiplegia. Ann Neurol 82:766-780
Kuo, Hsing-Ching; Gordon, Andrew M; Henrionnet, Aline et al. (2016) The effects of intensive bimanual training with and without tactile training on tactile function in children with unilateral spastic cerebral palsy: A pilot study. Res Dev Disabil 49-50:129-39
Friel, Kathleen M; Kuo, Hsing-Ching; Fuller, Jason et al. (2016) Skilled Bimanual Training Drives Motor Cortex Plasticity in Children With Unilateral Cerebral Palsy. Neurorehabil Neural Repair 30:834-44
Bleyenheuft, Yannick; Dricot, Laurence; Gilis, Nathalie et al. (2015) Capturing neuroplastic changes after bimanual intensive rehabilitation in children with unilateral spastic cerebral palsy: A combined DTI, TMS and fMRI pilot study. Res Dev Disabil 43-44:136-49